Human leukocyte antigen (HLA)-G and cervical cancer immunoediting: A candidate molecule for therapeutic intervention and prognostic biomarker?

Fabrícia Gimenes, Jorge Juarez Vieira Teixeira, André Luelsdorf Pimenta de Abreu, Raquel Pantarotto Souza, Monalisa Wolski Pereira, Vânia Ramos Sela da Silva, Cinthia Gandolfi BÔer, Silvya Stuchi Maria-Engler, Marcelo Gialluisi Bonini, Sueli Donizete Borelli, Márcia Edilaine Lopes Consolaro*

*Corresponding author for this work

Research output: Contribution to journalReview article

22 Scopus citations

Abstract

While persistent infection with oncogenic types of human Papillomavirus (HPV) is required for cervical epithelial cell transformation and cervical carcinogenesis, HPV infection alone is not sufficient to induce tumorigenesis. Only a minor fraction of HPV infections produce high-grade lesions and cervical cancer, suggesting complex host-virus interactions. Based on its pronounced immunoinhibitory properties, human leukocyte antigen (HLA)-G has been proposed as a possible prognostic biomarker and therapeutic target relevant in a wide variety of cancers and viral infections, but to date remains underexplored in cervical cancer. Given the possible influence of HLA-G on the clinical course of HPV infection, cervical lesions and cancer progression, a better understanding of HLA-G involvement in cervical carcinogenesis might contribute to two aspects of fundamental importance: 1. Characterization of a novel diagnostic/prognostic biomarker to identify cervical cancer and to monitor disease stage, critical for patient screening; 2. Identification of HLA-G-driven immune mechanisms involved in lesion development and cancer progression, leading to the development of strategies for modulating HLA-G expression for treatment purposes. Thus, this systematic review explores the potential involvement of HLA-G protein expression and polymorphisms in cervical carcinogenesis.

Original languageEnglish (US)
Pages (from-to)576-589
Number of pages14
JournalBiochimica et Biophysica Acta - Reviews on Cancer
Volume1846
Issue number2
DOIs
StatePublished - Dec 1 2014
Externally publishedYes

Keywords

  • Cancer immunoediting
  • Cervical cancer
  • HLA-G
  • HPV
  • Prognostic biomarker
  • Therapeutic intervention

ASJC Scopus subject areas

  • Oncology
  • Genetics
  • Cancer Research

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    Gimenes, F., Teixeira, J. J. V., de Abreu, A. L. P., Souza, R. P., Pereira, M. W., da Silva, V. R. S., BÔer, C. G., Maria-Engler, S. S., Bonini, M. G., Borelli, S. D., & Consolaro, M. E. L. (2014). Human leukocyte antigen (HLA)-G and cervical cancer immunoediting: A candidate molecule for therapeutic intervention and prognostic biomarker? Biochimica et Biophysica Acta - Reviews on Cancer, 1846(2), 576-589. https://doi.org/10.1016/j.bbcan.2014.10.004