TY - JOUR
T1 - Human leukocyte antigen (HLA)-G and cervical cancer immunoediting
T2 - A candidate molecule for therapeutic intervention and prognostic biomarker?
AU - Gimenes, Fabrícia
AU - Teixeira, Jorge Juarez Vieira
AU - de Abreu, André Luelsdorf Pimenta
AU - Souza, Raquel Pantarotto
AU - Pereira, Monalisa Wolski
AU - da Silva, Vânia Ramos Sela
AU - BÔer, Cinthia Gandolfi
AU - Maria-Engler, Silvya Stuchi
AU - Bonini, Marcelo Gialluisi
AU - Borelli, Sueli Donizete
AU - Consolaro, Márcia Edilaine Lopes
N1 - Funding Information:
The authors wish to acknowledge financial support from the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) of Brazilian Government (PRODOC 2571/2010 and PVE A109/2013 ).
PY - 2014/12/1
Y1 - 2014/12/1
N2 - While persistent infection with oncogenic types of human Papillomavirus (HPV) is required for cervical epithelial cell transformation and cervical carcinogenesis, HPV infection alone is not sufficient to induce tumorigenesis. Only a minor fraction of HPV infections produce high-grade lesions and cervical cancer, suggesting complex host-virus interactions. Based on its pronounced immunoinhibitory properties, human leukocyte antigen (HLA)-G has been proposed as a possible prognostic biomarker and therapeutic target relevant in a wide variety of cancers and viral infections, but to date remains underexplored in cervical cancer. Given the possible influence of HLA-G on the clinical course of HPV infection, cervical lesions and cancer progression, a better understanding of HLA-G involvement in cervical carcinogenesis might contribute to two aspects of fundamental importance: 1. Characterization of a novel diagnostic/prognostic biomarker to identify cervical cancer and to monitor disease stage, critical for patient screening; 2. Identification of HLA-G-driven immune mechanisms involved in lesion development and cancer progression, leading to the development of strategies for modulating HLA-G expression for treatment purposes. Thus, this systematic review explores the potential involvement of HLA-G protein expression and polymorphisms in cervical carcinogenesis.
AB - While persistent infection with oncogenic types of human Papillomavirus (HPV) is required for cervical epithelial cell transformation and cervical carcinogenesis, HPV infection alone is not sufficient to induce tumorigenesis. Only a minor fraction of HPV infections produce high-grade lesions and cervical cancer, suggesting complex host-virus interactions. Based on its pronounced immunoinhibitory properties, human leukocyte antigen (HLA)-G has been proposed as a possible prognostic biomarker and therapeutic target relevant in a wide variety of cancers and viral infections, but to date remains underexplored in cervical cancer. Given the possible influence of HLA-G on the clinical course of HPV infection, cervical lesions and cancer progression, a better understanding of HLA-G involvement in cervical carcinogenesis might contribute to two aspects of fundamental importance: 1. Characterization of a novel diagnostic/prognostic biomarker to identify cervical cancer and to monitor disease stage, critical for patient screening; 2. Identification of HLA-G-driven immune mechanisms involved in lesion development and cancer progression, leading to the development of strategies for modulating HLA-G expression for treatment purposes. Thus, this systematic review explores the potential involvement of HLA-G protein expression and polymorphisms in cervical carcinogenesis.
KW - Cancer immunoediting
KW - Cervical cancer
KW - HLA-G
KW - HPV
KW - Prognostic biomarker
KW - Therapeutic intervention
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U2 - 10.1016/j.bbcan.2014.10.004
DO - 10.1016/j.bbcan.2014.10.004
M3 - Review article
C2 - 25453366
AN - SCOPUS:84908576795
SN - 0304-419X
VL - 1846
SP - 576
EP - 589
JO - Biochimica et Biophysica Acta - Reviews on Cancer
JF - Biochimica et Biophysica Acta - Reviews on Cancer
IS - 2
ER -
