Human lung mast cell and alveolar macrophage cytoplasmic lipid bodies contain arachidonic acid and prostaglandin endoperoxide synthase (Cyclooxygenase), the substrate and enzyme necessary for prostaglandin production

Ann M. Dvorak*, Robert P. Schleimer, Harold F. Dvorak, Lawrence M. Lichtenstein, Peter F. Weller

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

Lipid bodies are non-membrane-bound cytoplasmic organelles that are preva-lent in mammalian cells of diverse lineages and that have been observed to increase in cells involved in inflammatory responses. Specialized morpholog-ical and biochemical studies have provided evidence for the involvement of lipid bodies in eicosanoid synthesis.

Original languageEnglish (US)
Pages (from-to)208-217
Number of pages10
JournalInternational archives of allergy and immunology
Volume99
Issue number2-4
DOIs
StatePublished - Jan 1 1992

Keywords

  • Arachidonic acid
  • Autoradiography
  • Cyclooxygenase
  • Immunocytochemistry
  • Lipid bodies
  • Macrophage
  • Mast cell
  • Prostaglandin
  • Subcellular fractionation
  • Ultrastructure

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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