Human lung mast cell and alveolar macrophage cytoplasmic lipid bodies contain arachidonic acid and prostaglandin endoperoxide synthase (Cyclooxygenase), the substrate and enzyme necessary for prostaglandin production

Ann M. Dvorak; Robert P. Schleimer; Harold F. Dvorak; Lawrence M. Lichtenstein; Peter F. Weller

doi:10.1159/000236250

Human lung mast cell and alveolar macrophage cytoplasmic lipid bodies contain arachidonic acid and prostaglandin endoperoxide synthase (Cyclooxygenase), the substrate and enzyme necessary for prostaglandin production

Ann M. Dvorak^*, Robert P. Schleimer, Harold F. Dvorak, Lawrence M. Lichtenstein, Peter F. Weller

^*Corresponding author for this work

Medicine, Allergy Division

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Lipid bodies are non-membrane-bound cytoplasmic organelles that are preva-lent in mammalian cells of diverse lineages and that have been observed to increase in cells involved in inflammatory responses. Specialized morpholog-ical and biochemical studies have provided evidence for the involvement of lipid bodies in eicosanoid synthesis.

Original language	English (US)
Pages (from-to)	208-217
Number of pages	10
Journal	International archives of allergy and immunology
Volume	99
Issue number	2-4
DOIs	https://doi.org/10.1159/000236250
State	Published - 1992

Keywords

Arachidonic acid
Autoradiography
Cyclooxygenase
Immunocytochemistry
Lipid bodies
Macrophage
Mast cell
Prostaglandin
Subcellular fractionation
Ultrastructure

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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Dvorak, A. M., Schleimer, R. P., Dvorak, H. F., Lichtenstein, L. M., & Weller, P. F. (1992). Human lung mast cell and alveolar macrophage cytoplasmic lipid bodies contain arachidonic acid and prostaglandin endoperoxide synthase (Cyclooxygenase), the substrate and enzyme necessary for prostaglandin production. International archives of allergy and immunology, 99(2-4), 208-217. https://doi.org/10.1159/000236250

Dvorak, Ann M. ; Schleimer, Robert P. ; Dvorak, Harold F. et al. / Human lung mast cell and alveolar macrophage cytoplasmic lipid bodies contain arachidonic acid and prostaglandin endoperoxide synthase (Cyclooxygenase), the substrate and enzyme necessary for prostaglandin production. In: International archives of allergy and immunology. 1992 ; Vol. 99, No. 2-4. pp. 208-217.

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title = "Human lung mast cell and alveolar macrophage cytoplasmic lipid bodies contain arachidonic acid and prostaglandin endoperoxide synthase (Cyclooxygenase), the substrate and enzyme necessary for prostaglandin production",

abstract = "Lipid bodies are non-membrane-bound cytoplasmic organelles that are preva-lent in mammalian cells of diverse lineages and that have been observed to increase in cells involved in inflammatory responses. Specialized morpholog-ical and biochemical studies have provided evidence for the involvement of lipid bodies in eicosanoid synthesis.",

keywords = "Arachidonic acid, Autoradiography, Cyclooxygenase, Immunocytochemistry, Lipid bodies, Macrophage, Mast cell, Prostaglandin, Subcellular fractionation, Ultrastructure",

author = "Dvorak, {Ann M.} and Schleimer, {Robert P.} and Dvorak, {Harold F.} and Lichtenstein, {Lawrence M.} and Weller, {Peter F.}",

year = "1992",

doi = "10.1159/000236250",

language = "English (US)",

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pages = "208--217",

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Dvorak, AM, Schleimer, RP, Dvorak, HF, Lichtenstein, LM & Weller, PF 1992, 'Human lung mast cell and alveolar macrophage cytoplasmic lipid bodies contain arachidonic acid and prostaglandin endoperoxide synthase (Cyclooxygenase), the substrate and enzyme necessary for prostaglandin production', International archives of allergy and immunology, vol. 99, no. 2-4, pp. 208-217. https://doi.org/10.1159/000236250

Human lung mast cell and alveolar macrophage cytoplasmic lipid bodies contain arachidonic acid and prostaglandin endoperoxide synthase (Cyclooxygenase), the substrate and enzyme necessary for prostaglandin production. / Dvorak, Ann M.; Schleimer, Robert P.; Dvorak, Harold F. et al.

In: International archives of allergy and immunology, Vol. 99, No. 2-4, 1992, p. 208-217.

Research output: Contribution to journal › Article › peer-review

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AU - Dvorak, Harold F.

AU - Lichtenstein, Lawrence M.

AU - Weller, Peter F.

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AB - Lipid bodies are non-membrane-bound cytoplasmic organelles that are preva-lent in mammalian cells of diverse lineages and that have been observed to increase in cells involved in inflammatory responses. Specialized morpholog-ical and biochemical studies have provided evidence for the involvement of lipid bodies in eicosanoid synthesis.

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KW - Autoradiography

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KW - Prostaglandin

KW - Subcellular fractionation

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Dvorak AM, Schleimer RP, Dvorak HF, Lichtenstein LM, Weller PF. Human lung mast cell and alveolar macrophage cytoplasmic lipid bodies contain arachidonic acid and prostaglandin endoperoxide synthase (Cyclooxygenase), the substrate and enzyme necessary for prostaglandin production. International archives of allergy and immunology. 1992;99(2-4):208-217. doi: 10.1159/000236250

Human lung mast cell and alveolar macrophage cytoplasmic lipid bodies contain arachidonic acid and prostaglandin endoperoxide synthase (Cyclooxygenase), the substrate and enzyme necessary for prostaglandin production

Abstract

Keywords

ASJC Scopus subject areas

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