Human milk growth factors and their role in nec prevention: A narrative review

Daniel J. York; Anne L. Smazal; Daniel T. Robinson; Isabelle G. De Plaen

doi:10.3390/nu13113751

Human milk growth factors and their role in nec prevention: A narrative review

Daniel J. York, Anne L. Smazal, Daniel T. Robinson, Isabelle G. De Plaen^*

^*Corresponding author for this work

Pediatrics

Research output: Contribution to journal › Review article › peer-review

23 Scopus citations

Abstract

Growing evidence demonstrates human milk’s protective effect against necrotizing enter-ocolitis (NEC). Human milk derives these properties from biologically active compounds that influence intestinal growth, barrier function, microvascular development, and immunological matu-ration. Among these protective compounds are growth factors that are secreted into milk with rel-atively high concentrations during the early postnatal period, when newborns are most susceptible to NEC. This paper reviews the current knowledge on human milk growth factors and their mechanisms of action relevant to NEC prevention. It will also discuss the stability of these growth factors with human milk pasteurization and their potential for use as supplements to infant formulas with the goal of preventing NEC.

Original language	English (US)
Article number	3751
Journal	Nutrients
Volume	13
Issue number	11
DOIs	https://doi.org/10.3390/nu13113751
State	Published - Nov 2021

Funding

Funding: This work was funded by the National Institute of Health Grant R01 DK116568 (I.G. De Plaen) and the Ann & Robert H. Lurie Children’s Hospital of Chicago (Division of Neonatology).

Keywords

Epidermal Growth Factor (EGF)
Erythropoetin (EPO)
Granulocyte Colony Stimulating Factor (G-CSF)
Growth factors
Heparin-Binding EGF-like Growth Factor (HB-EGF)
Holder pasteurization
Human milk
Insulin-like Growth Factor 1 (IGF-1) Insulin-like Growth Factor 2 (IGF-2)
Necrotizing enterocolitis
Vascular Endothelial Growth Factor (VEGF)

ASJC Scopus subject areas

Food Science
Nutrition and Dietetics

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10.3390/nu13113751

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title = "Human milk growth factors and their role in nec prevention: A narrative review",

abstract = "Growing evidence demonstrates human milk{\textquoteright}s protective effect against necrotizing enter-ocolitis (NEC). Human milk derives these properties from biologically active compounds that influence intestinal growth, barrier function, microvascular development, and immunological matu-ration. Among these protective compounds are growth factors that are secreted into milk with rel-atively high concentrations during the early postnatal period, when newborns are most susceptible to NEC. This paper reviews the current knowledge on human milk growth factors and their mechanisms of action relevant to NEC prevention. It will also discuss the stability of these growth factors with human milk pasteurization and their potential for use as supplements to infant formulas with the goal of preventing NEC.",

keywords = "Epidermal Growth Factor (EGF), Erythropoetin (EPO), Granulocyte Colony Stimulating Factor (G-CSF), Growth factors, Heparin-Binding EGF-like Growth Factor (HB-EGF), Holder pasteurization, Human milk, Insulin-like Growth Factor 1 (IGF-1) Insulin-like Growth Factor 2 (IGF-2), Necrotizing enterocolitis, Vascular Endothelial Growth Factor (VEGF)",

author = "York, {Daniel J.} and Smazal, {Anne L.} and Robinson, {Daniel T.} and {De Plaen}, {Isabelle G.}",

note = "Funding Information: Funding: This work was funded by the National Institute of Health Grant R01 DK116568 (I.G. De Plaen) and the Ann & Robert H. Lurie Children{\textquoteright}s Hospital of Chicago (Division of Neonatology). Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2021",

month = nov,

doi = "10.3390/nu13113751",

language = "English (US)",

volume = "13",

journal = "Nutrients",

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T2 - A narrative review

AU - York, Daniel J.

AU - Smazal, Anne L.

AU - Robinson, Daniel T.

AU - De Plaen, Isabelle G.

N1 - Funding Information: Funding: This work was funded by the National Institute of Health Grant R01 DK116568 (I.G. De Plaen) and the Ann & Robert H. Lurie Children’s Hospital of Chicago (Division of Neonatology). Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.

PY - 2021/11

Y1 - 2021/11

N2 - Growing evidence demonstrates human milk’s protective effect against necrotizing enter-ocolitis (NEC). Human milk derives these properties from biologically active compounds that influence intestinal growth, barrier function, microvascular development, and immunological matu-ration. Among these protective compounds are growth factors that are secreted into milk with rel-atively high concentrations during the early postnatal period, when newborns are most susceptible to NEC. This paper reviews the current knowledge on human milk growth factors and their mechanisms of action relevant to NEC prevention. It will also discuss the stability of these growth factors with human milk pasteurization and their potential for use as supplements to infant formulas with the goal of preventing NEC.

AB - Growing evidence demonstrates human milk’s protective effect against necrotizing enter-ocolitis (NEC). Human milk derives these properties from biologically active compounds that influence intestinal growth, barrier function, microvascular development, and immunological matu-ration. Among these protective compounds are growth factors that are secreted into milk with rel-atively high concentrations during the early postnatal period, when newborns are most susceptible to NEC. This paper reviews the current knowledge on human milk growth factors and their mechanisms of action relevant to NEC prevention. It will also discuss the stability of these growth factors with human milk pasteurization and their potential for use as supplements to infant formulas with the goal of preventing NEC.

KW - Epidermal Growth Factor (EGF)

KW - Erythropoetin (EPO)

KW - Granulocyte Colony Stimulating Factor (G-CSF)

KW - Growth factors

KW - Heparin-Binding EGF-like Growth Factor (HB-EGF)

KW - Holder pasteurization

KW - Human milk

KW - Insulin-like Growth Factor 1 (IGF-1) Insulin-like Growth Factor 2 (IGF-2)

KW - Necrotizing enterocolitis

KW - Vascular Endothelial Growth Factor (VEGF)

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DO - 10.3390/nu13113751

M3 - Review article

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AN - SCOPUS:85117499913

SN - 2072-6643

VL - 13

JO - Nutrients

JF - Nutrients

IS - 11

M1 - 3751

ER -

Human milk growth factors and their role in nec prevention: A narrative review

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ASJC Scopus subject areas

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