Human olfactory-auditory integration requires phase synchrony between sensory cortices

Guangyu Zhou; Gregory Lane; Torben Noto; Ghazaleh Arabkheradmand; Jay A. Gottfried; Stephan U. Schuele; Joshua M. Rosenow; Jonas K. Olofsson; Donald A. Wilson; Christina Zelano

doi:10.1038/s41467-019-09091-3

Human olfactory-auditory integration requires phase synchrony between sensory cortices

Guangyu Zhou^*, Gregory Lane, Torben Noto, Ghazaleh Arabkheradmand, Jay A. Gottfried, Stephan U. Schuele, Joshua M. Rosenow, Jonas K. Olofsson, Donald A. Wilson, Christina Zelano

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

Abstract

Multisensory integration is particularly important in the human olfactory system, which is highly dependent on non-olfactory cues, yet its underlying neural mechanisms are not well understood. In this study, we use intracranial electroencephalography techniques to record neural activity in auditory and olfactory cortices during an auditory-olfactory matching task. Spoken cues evoke phase locking between low frequency oscillations in auditory and olfactory cortices prior to odor arrival. This phase synchrony occurs only when the participant’s later response is correct. Furthermore, the phase of low frequency oscillations in both auditory and olfactory cortical areas couples to the amplitude of high-frequency oscillations in olfactory cortex during correct trials. These findings suggest that phase synchrony is a fundamental mechanism for integrating cross-modal odor processing and highlight an important role for primary olfactory cortical areas in multisensory integration with the olfactory system.

Original language	English (US)
Article number	1168
Journal	Nature communications
Volume	10
Issue number	1
DOIs	https://doi.org/10.1038/s41467-019-09091-3
State	Published - Dec 1 2019

Funding

We thank Jeremy Eagles, Enelsa Lopez, and Navid Shadlou for their technical support and assistance with data collection. This work was supported by National Institutes of Health grants from the National Institute on Deafness and Other Communication Disorders (NIDCD) (R00-DC-012803 and R01-DC-016364 to C.Z.), The National Institute of Neurological Disorders and Stroke (NINDS) (T32-NS047987 to T.N.), and The Knut and Alice Wallenberg Foundation (KAW 2016:0229 to JKO).

ASJC Scopus subject areas

General Chemistry
General Biochemistry, Genetics and Molecular Biology
General Physics and Astronomy

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abstract = "Multisensory integration is particularly important in the human olfactory system, which is highly dependent on non-olfactory cues, yet its underlying neural mechanisms are not well understood. In this study, we use intracranial electroencephalography techniques to record neural activity in auditory and olfactory cortices during an auditory-olfactory matching task. Spoken cues evoke phase locking between low frequency oscillations in auditory and olfactory cortices prior to odor arrival. This phase synchrony occurs only when the participant{\textquoteright}s later response is correct. Furthermore, the phase of low frequency oscillations in both auditory and olfactory cortical areas couples to the amplitude of high-frequency oscillations in olfactory cortex during correct trials. These findings suggest that phase synchrony is a fundamental mechanism for integrating cross-modal odor processing and highlight an important role for primary olfactory cortical areas in multisensory integration with the olfactory system.",

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AU - Gottfried, Jay A.

AU - Schuele, Stephan U.

AU - Rosenow, Joshua M.

AU - Olofsson, Jonas K.

AU - Wilson, Donald A.

AU - Zelano, Christina

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Human olfactory-auditory integration requires phase synchrony between sensory cortices

Abstract

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