Human papillomavirus and the DNA damage response: Exploiting host repair pathways for viral replication

Chelsey C. Spriggs, Laimonis A. Laimins*

*Corresponding author for this work

Research output: Contribution to journalReview article

15 Scopus citations

Abstract

High-risk human papillomaviruses (HPVs) are the causative agents of cervical and other genital cancers. In addition, HPV infections are associated with the development of many oropharyngeal cancers. HPVs activate and repress a number of host cellular pathways to promote their viral life cycles, including those of the DNA damage response. High-risk HPVs activate the ataxia telangiectasia-mutated (ATM) and ATM and Rad3-related (ATR) DNA damage repair pathways, which are essential for viral replication (particularly differentiation-dependent genome amplification). These DNA repair pathways are critical in maintaining host genomic integrity and stability and are often dysregulated or mutated in human cancers. Understanding how these pathways contribute to HPV replication and transformation may lead to the identification of new therapeutic targets for the treatment of existing HPV infections.

Original languageEnglish (US)
Article number232
JournalViruses
Volume9
Issue number8
DOIs
StatePublished - Feb 18 2017

Keywords

  • DNA damage response
  • Human papillomavirus
  • Replication

ASJC Scopus subject areas

  • Infectious Diseases
  • Virology

Fingerprint Dive into the research topics of 'Human papillomavirus and the DNA damage response: Exploiting host repair pathways for viral replication'. Together they form a unique fingerprint.

  • Cite this