TY - JOUR
T1 - Human papillomavirus oncoproteins
T2 - Pathways to transformation
AU - Moody, Cary A.
AU - Laimins, Laimonis A.
N1 - Funding Information:
L.A.L. is supported by grants from the National Cancer Institute and the National Institute for Allergy and Infectious Diseases. C.A.M. is supported by a K99 Pathway to Independence Award from the National Cancer Institute. We thank K. Simanis for assistance with the figures.
PY - 2010/8
Y1 - 2010/8
N2 - An association between human papillomavirus (HPV) infection and the development of cervical cancer was initially reported over 30 years ago, and today there is overwhelming evidence that certain subtypes of HPV are the causative agents of these malignancies. The p53 and retinoblastoma proteins are well-characterized targets of the HPV E6 and E7 oncoproteins, but recent studies have shown that the alteration of additional pathways are equally important for transformation. These additional factors are crucial regulators of cell cycle progression, telomere maintenance, apoptosis and chromosomal stability. Understanding how HPV oncoproteins modify these activities provides novel insights into the basic mechanisms of oncogenesis.
AB - An association between human papillomavirus (HPV) infection and the development of cervical cancer was initially reported over 30 years ago, and today there is overwhelming evidence that certain subtypes of HPV are the causative agents of these malignancies. The p53 and retinoblastoma proteins are well-characterized targets of the HPV E6 and E7 oncoproteins, but recent studies have shown that the alteration of additional pathways are equally important for transformation. These additional factors are crucial regulators of cell cycle progression, telomere maintenance, apoptosis and chromosomal stability. Understanding how HPV oncoproteins modify these activities provides novel insights into the basic mechanisms of oncogenesis.
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U2 - 10.1038/nrc2886
DO - 10.1038/nrc2886
M3 - Review article
C2 - 20592731
AN - SCOPUS:77954955259
SN - 1474-175X
VL - 10
SP - 550
EP - 560
JO - Nature Reviews Cancer
JF - Nature Reviews Cancer
IS - 8
ER -
