Abstract
An association between human papillomavirus (HPV) infection and the development of cervical cancer was initially reported over 30 years ago, and today there is overwhelming evidence that certain subtypes of HPV are the causative agents of these malignancies. The p53 and retinoblastoma proteins are well-characterized targets of the HPV E6 and E7 oncoproteins, but recent studies have shown that the alteration of additional pathways are equally important for transformation. These additional factors are crucial regulators of cell cycle progression, telomere maintenance, apoptosis and chromosomal stability. Understanding how HPV oncoproteins modify these activities provides novel insights into the basic mechanisms of oncogenesis.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 550-560 |
| Number of pages | 11 |
| Journal | Nature Reviews Cancer |
| Volume | 10 |
| Issue number | 8 |
| DOIs | |
| State | Published - Aug 2010 |
Funding
L.A.L. is supported by grants from the National Cancer Institute and the National Institute for Allergy and Infectious Diseases. C.A.M. is supported by a K99 Pathway to Independence Award from the National Cancer Institute. We thank K. Simanis for assistance with the figures.
ASJC Scopus subject areas
- Oncology
- Cancer Research
