Human papillomavirus oncoproteins: Pathways to transformation

Cary A. Moody, Laimonis A Laimins

Research output: Contribution to journalReview articlepeer-review

913 Scopus citations

Abstract

An association between human papillomavirus (HPV) infection and the development of cervical cancer was initially reported over 30 years ago, and today there is overwhelming evidence that certain subtypes of HPV are the causative agents of these malignancies. The p53 and retinoblastoma proteins are well-characterized targets of the HPV E6 and E7 oncoproteins, but recent studies have shown that the alteration of additional pathways are equally important for transformation. These additional factors are crucial regulators of cell cycle progression, telomere maintenance, apoptosis and chromosomal stability. Understanding how HPV oncoproteins modify these activities provides novel insights into the basic mechanisms of oncogenesis.

Original languageEnglish (US)
Pages (from-to)550-560
Number of pages11
JournalNature Reviews Cancer
Volume10
Issue number8
DOIs
StatePublished - Aug 1 2010

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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