Abstract
Human papillomaviruses (HPVs) modulate expression of host microRNAs. Our deep-sequencing analysis of organotypic raft cultures identified microRNA 145 (miR-145) as a differentiation-dependent microRNA that has functionally active target sequences in the HPV-31 E1 and E2 open reading frames. Overexpression of miR-145 in HPV-positive cells resulted inreduced genome amplification and late gene expression, along with decreased levels of cellular transcription factor KLF-4. Our studies show that HPV modulates miR-145 expression to control its own life cycle
Original language | English (US) |
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Pages (from-to) | 6037-6043 |
Number of pages | 7 |
Journal | Journal of virology |
Volume | 87 |
Issue number | 10 |
DOIs | |
State | Published - May 2013 |
ASJC Scopus subject areas
- Microbiology
- Immunology
- Insect Science
- Virology