Human papillomaviruses recruit cellular DNA repair and homologous recombination factors to viral replication centers

Kenric A. Gillespie, Kavi P. Mehta, Laimonis A. Laimins, Cary A. Moody*

*Corresponding author for this work

Research output: Contribution to journalArticle

117 Scopus citations

Abstract

Human papillomaviruses (HPV) activate the ataxia telangiectasia mutated (ATM)-dependent DNA damage response to induce viral genome amplification upon epithelial differentiation. Our studies show that along with members of the ATM pathway, HPV proteins also localize factors involved in homologous DNA recombination to distinct nuclear foci that contain HPV genomes and cellular replication factors. These studies indicate that HPV activates the ATM pathway to recruit repair factors to viral genomes and allow for efficient replication.

Original languageEnglish (US)
Pages (from-to)9520-9526
Number of pages7
JournalJournal of virology
Volume86
Issue number17
DOIs
StatePublished - Sep 2012

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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