Human papillomaviruses: Shared and distinct pathways for pathogenesis

Denise A. Galloway*, Laimonis A. Laimins

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

46 Scopus citations

Abstract

Over 200 types of human papillomaviruses (HPV) have been identified that infect epithelial cells at different anatomic locations. HPVs are grouped into five genera with the alpha and beta viruses being the most commonly studied. Members of the alpha HPV genus infect genital epithelia and are the causative agents of many anogenital cancers. Beta HPVs infect cutaneous epithelia and have been suggested as co-factors in the development of non-melanoma skin cancers. Recent studies have shown that activation of DNA damage pathways is important for the productive life cycle of the alpha HPVs while the beta viruses suppress their activation. These differences likely contribute to the varying types of lesions and malignancies that are associated with these viruses.

Original languageEnglish (US)
Pages (from-to)87-92
Number of pages6
JournalCurrent Opinion in Virology
Volume14
DOIs
StatePublished - Oct 1 2015

ASJC Scopus subject areas

  • Virology

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