Human papillomaviruses: Targeting differentiating epithelial cells for malignant transformation

Frauke Fehrmann, Laimonis A. Laimins*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

201 Scopus citations

Abstract

Human papillomavirus (HPV) infections play a crucial role in the pathogenesis of cervical neoplasia. Insights into the mechanisms by which HPV infection can, in a small numbers of cases, result in malignancy, comes from the observation that three proteins encoded by high-risk genital HPVs, E6, E7 and to a lesser extent E5, target factors that control the cell cycle and proliferation. These interactions result in abrogation of cell cycle control, chromosomal alterations, telomerase activation, and eventual cell immortalization. In this review, we discuss the functions of E6, E7, and E5 proteins that are most relevant to the malignant progression of HPV-transformed cells.

Original languageEnglish (US)
Pages (from-to)5201-5207
Number of pages7
JournalOncogene
Volume22
Issue number33 REV. ISS. 2
DOIs
StatePublished - Aug 11 2003

Keywords

  • Cervical cancer
  • E5
  • E6
  • E7
  • HPV
  • Oncoproteins

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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