TY - JOUR
T1 - Human Proteinpedia
T2 - A unified discovery resource for proteomics research
AU - Kandasamy, Kumaran
AU - Keerthikumar, Shivakumar
AU - Goel, Renu
AU - Mathivanan, Suresh
AU - Patankar, Nandini
AU - Shafreen, Beema
AU - Renuse, Santosh
AU - Pawar, Harsh
AU - Ramachandra, Y. L.
AU - Acharya, Pradip Kumar
AU - Ranganathan, Prathibha
AU - Chaerkady, Raghothama
AU - Keshava Prasad, T. S.
AU - Pandey, Akhilesh
N1 - Funding Information:
National Institutes of Health (U54 RR020839); Roadmap Initiative for Technology Centers for Networks and Pathways, partially. Funding for open access charge: National Institutes of Health (U54 RR020839).
PY - 2009
Y1 - 2009
N2 - Sharing proteomic data with the biomedical community through a unified proteomic resource, especially in the context of individual proteins, is a challenging prospect. We have developed a community portal, designated as Human Proteinpedia (http://www.humanproteinpedia.org/), for sharing both unpublished and published human proteomic data through the use of a distributed annotation system designed specifically for this purpose. This system allows laboratories to contribute and maintain protein annotations, which are also mapped to the corresponding proteins through the Human Protein Reference Database (HPRD; http://www.hprd.org/). Thus, it is possible to visualize data pertaining to experimentally validated posttranslational modifications (PTMs), protein isoforms, protein-protein interactions (PPIs), tissue expression, expression in cell lines, subcellular localization and enzyme substrates in the context of individual proteins. With enthusiastic participation of the proteomics community, the past 15 months have witnessed data contributions from more than 75 labs around the world including 2710 distinct experiments, < 1.9 million peptides, < 4.8 million MS/MS spectra, 150 368 protein expression annotations, 17 410 PTMs, 34 624 PPIs and 2906 subcellular localization annotations. Human Proteinpedia should serve as an integrated platform to store, integrate and disseminate such proteomic data and is inching towards evolving into a unified human proteomics resource.
AB - Sharing proteomic data with the biomedical community through a unified proteomic resource, especially in the context of individual proteins, is a challenging prospect. We have developed a community portal, designated as Human Proteinpedia (http://www.humanproteinpedia.org/), for sharing both unpublished and published human proteomic data through the use of a distributed annotation system designed specifically for this purpose. This system allows laboratories to contribute and maintain protein annotations, which are also mapped to the corresponding proteins through the Human Protein Reference Database (HPRD; http://www.hprd.org/). Thus, it is possible to visualize data pertaining to experimentally validated posttranslational modifications (PTMs), protein isoforms, protein-protein interactions (PPIs), tissue expression, expression in cell lines, subcellular localization and enzyme substrates in the context of individual proteins. With enthusiastic participation of the proteomics community, the past 15 months have witnessed data contributions from more than 75 labs around the world including 2710 distinct experiments, < 1.9 million peptides, < 4.8 million MS/MS spectra, 150 368 protein expression annotations, 17 410 PTMs, 34 624 PPIs and 2906 subcellular localization annotations. Human Proteinpedia should serve as an integrated platform to store, integrate and disseminate such proteomic data and is inching towards evolving into a unified human proteomics resource.
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U2 - 10.1093/nar/gkn701
DO - 10.1093/nar/gkn701
M3 - Article
C2 - 18948298
AN - SCOPUS:58149202157
SN - 0305-1048
VL - 37
SP - D773-D781
JO - Nucleic acids research
JF - Nucleic acids research
IS - SUPPL. 1
ER -