Human rhinovirus models in asthma

A. Singh, W. Busse*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Abstract

In both children and adults, rhinovirus (RV) infections remain a major cause of exacerbations in asthma. With the use of both in vitro models of RV infection and experimental models of asthma exacerbation in humans, insight into the precise role of RV in this process has been obtained. RV infects the lower airways, and the virus itself, together with the immune response to the virus, leads to increased airway obstruction in some patients with asthma. Defects in the immune response to RV in these patients may also lead to increased symptom severity and to more significant exacerbations. Work further investigating the mechanisms of exacerbation caused by RV infection will ultimately lead to new modalities of treatment and possibly prevention of this common and significant cause of acute asthma.

Original languageEnglish (US)
Title of host publicationModels of Exacerbations in Asthma and COPD
EditorsU. Sjobring, J.D. Taylor
Pages12-20
Number of pages9
DOIs
StatePublished - Dec 1 2007

Publication series

NameContributions to Microbiology
Volume14
ISSN (Print)1420-9519
ISSN (Electronic)1662-291X

ASJC Scopus subject areas

  • Immunology and Microbiology(all)
  • Microbiology (medical)
  • Infectious Diseases

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