Human Schlafen 5 (SLFN5) is a regulator of motility and invasiveness of renal cell carcinoma cells

Antonella Sassano; Evangelos Mavrommatis; Ahmet Dirim Arslan; Barbara Kroczynska; Elspeth M. Beauchamp; Satya Khuon; Ten Leong Chew; Kathleen J. Green; Hidayatullah G. Munshi; Amit K. Verma; Leonidas C. Platanias

doi:10.1128/MCB.00019-15

Human Schlafen 5 (SLFN5) is a regulator of motility and invasiveness of renal cell carcinoma cells

Antonella Sassano, Evangelos Mavrommatis, Ahmet Dirim Arslan, Barbara Kroczynska, Elspeth M. Beauchamp, Satya Khuon, Ten Leong Chew, Kathleen J. Green, Hidayatullah G. Munshi, Amit K. Verma, Leonidas C. Platanias^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

48 Scopus citations

Abstract

We provide evidence that human SLFN5, an interferon (IFN)-inducible member of the Schlafen (SLFN) family of proteins, exhibits key roles in controlling motility and invasiveness of renal cell carcinoma (RCC) cells. Our studies define the mechanism by which this occurs, demonstrating that SLFN5 negatively controls expression of the matrix metalloproteinase 1 gene (MMP-1), MMP-13, and several other genes involved in the control of malignant cell motility. Importantly, our data establish that SLFN5 expression correlates with a better overall survival in a large cohort of patients with RCC. The inverse relationship between SLFN5 expression and RCC aggressiveness raises the possibility of developing unique therapeutic approaches in the treatment of RCC, by modulating SLFN5 expression.

Original language	English (US)
Pages (from-to)	2684-2698
Number of pages	15
Journal	Molecular and cellular biology
Volume	35
Issue number	15
DOIs	https://doi.org/10.1128/MCB.00019-15
State	Published - 2015

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ASJC Scopus subject areas

Molecular Biology
Cell Biology

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title = "Human Schlafen 5 (SLFN5) is a regulator of motility and invasiveness of renal cell carcinoma cells",

abstract = "We provide evidence that human SLFN5, an interferon (IFN)-inducible member of the Schlafen (SLFN) family of proteins, exhibits key roles in controlling motility and invasiveness of renal cell carcinoma (RCC) cells. Our studies define the mechanism by which this occurs, demonstrating that SLFN5 negatively controls expression of the matrix metalloproteinase 1 gene (MMP-1), MMP-13, and several other genes involved in the control of malignant cell motility. Importantly, our data establish that SLFN5 expression correlates with a better overall survival in a large cohort of patients with RCC. The inverse relationship between SLFN5 expression and RCC aggressiveness raises the possibility of developing unique therapeutic approaches in the treatment of RCC, by modulating SLFN5 expression.",

author = "Antonella Sassano and Evangelos Mavrommatis and Arslan, {Ahmet Dirim} and Barbara Kroczynska and Beauchamp, {Elspeth M.} and Satya Khuon and Chew, {Ten Leong} and Green, {Kathleen J.} and Munshi, {Hidayatullah G.} and Verma, {Amit K.} and Platanias, {Leonidas C.}",

note = "Publisher Copyright: {\textcopyright} 2015, American Society for Microbiology.",

year = "2015",

doi = "10.1128/MCB.00019-15",

language = "English (US)",

volume = "35",

pages = "2684--2698",

journal = "Molecular and cellular biology",

issn = "0270-7306",

publisher = "American Society for Microbiology",

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TY - JOUR

T1 - Human Schlafen 5 (SLFN5) is a regulator of motility and invasiveness of renal cell carcinoma cells

AU - Sassano, Antonella

AU - Mavrommatis, Evangelos

AU - Arslan, Ahmet Dirim

AU - Kroczynska, Barbara

AU - Beauchamp, Elspeth M.

AU - Khuon, Satya

AU - Chew, Ten Leong

AU - Green, Kathleen J.

AU - Munshi, Hidayatullah G.

AU - Verma, Amit K.

AU - Platanias, Leonidas C.

PY - 2015

Y1 - 2015

N2 - We provide evidence that human SLFN5, an interferon (IFN)-inducible member of the Schlafen (SLFN) family of proteins, exhibits key roles in controlling motility and invasiveness of renal cell carcinoma (RCC) cells. Our studies define the mechanism by which this occurs, demonstrating that SLFN5 negatively controls expression of the matrix metalloproteinase 1 gene (MMP-1), MMP-13, and several other genes involved in the control of malignant cell motility. Importantly, our data establish that SLFN5 expression correlates with a better overall survival in a large cohort of patients with RCC. The inverse relationship between SLFN5 expression and RCC aggressiveness raises the possibility of developing unique therapeutic approaches in the treatment of RCC, by modulating SLFN5 expression.

AB - We provide evidence that human SLFN5, an interferon (IFN)-inducible member of the Schlafen (SLFN) family of proteins, exhibits key roles in controlling motility and invasiveness of renal cell carcinoma (RCC) cells. Our studies define the mechanism by which this occurs, demonstrating that SLFN5 negatively controls expression of the matrix metalloproteinase 1 gene (MMP-1), MMP-13, and several other genes involved in the control of malignant cell motility. Importantly, our data establish that SLFN5 expression correlates with a better overall survival in a large cohort of patients with RCC. The inverse relationship between SLFN5 expression and RCC aggressiveness raises the possibility of developing unique therapeutic approaches in the treatment of RCC, by modulating SLFN5 expression.

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SN - 0270-7306

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SP - 2684

EP - 2698

JO - Molecular and cellular biology

JF - Molecular and cellular biology

IS - 15

ER -

Human Schlafen 5 (SLFN5) is a regulator of motility and invasiveness of renal cell carcinoma cells

Abstract

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