Human stem cells for modeling heart disease and for drug discovery

Elena Matsa; Paul W. Burridge; Joseph C. Wu

doi:10.1126/scitranslmed.3008921

Human stem cells for modeling heart disease and for drug discovery

Elena Matsa, Paul W. Burridge, Joseph C. Wu^*

^*Corresponding author for this work

Pharmacology

Research output: Contribution to journal › Review article › peer-review

148 Scopus citations

Abstract

A major research focus in the field of cardiovascular medicine is the prospect of using stem cells and progenitor cells for cardiac regeneration. With the advent of induced pluripotent stem cell (iPSC) technology, major efforts are also underway to use iPSCs to model heart disease, to screen for new drugs, and to test candidate drugs for cardiotoxicity. Here, we discuss recent advances in the exciting fields of stem cells and cardiovascular disease.

Original language	English (US)
Article number	239ps6
Journal	Science translational medicine
Volume	6
Issue number	239
DOIs	https://doi.org/10.1126/scitranslmed.3008921
State	Published - Jun 4 2014

ASJC Scopus subject areas

Medicine(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1126/scitranslmed.3008921

Cite this

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title = "Human stem cells for modeling heart disease and for drug discovery",

abstract = "A major research focus in the field of cardiovascular medicine is the prospect of using stem cells and progenitor cells for cardiac regeneration. With the advent of induced pluripotent stem cell (iPSC) technology, major efforts are also underway to use iPSCs to model heart disease, to screen for new drugs, and to test candidate drugs for cardiotoxicity. Here, we discuss recent advances in the exciting fields of stem cells and cardiovascular disease.",

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AB - A major research focus in the field of cardiovascular medicine is the prospect of using stem cells and progenitor cells for cardiac regeneration. With the advent of induced pluripotent stem cell (iPSC) technology, major efforts are also underway to use iPSCs to model heart disease, to screen for new drugs, and to test candidate drugs for cardiotoxicity. Here, we discuss recent advances in the exciting fields of stem cells and cardiovascular disease.

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Human stem cells for modeling heart disease and for drug discovery

Abstract

ASJC Scopus subject areas

UN SDGs

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