Human striatal cholinergic neurons in development, aging and Alzheimer's disease

Changiz Geula*, Hajime Tokuno, Louis Hersh, M. -Marsel Mesulam

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

The cross-sectional area of cholinergic neurons stained immunohistochemically for choline acetyltransferase were measured in the striatum of infants, young adults, aged individuals and patients with Alzheimer's disease. Cholinergic neurons were distributed throughout the caudate nucleus and the putamen and displayed no significant variations in size across the two structures. The cross-sectional area of striatal cholinergic neurons was smaller in infants as compared with all the other groups examined. No significant changes were observed in the size of these neurons as a consequence of aging or Alzheimer's disease.

Original languageEnglish (US)
Pages (from-to)310-312
Number of pages3
JournalBrain research
Volume508
Issue number2
DOIs
StatePublished - Feb 5 1990

Keywords

  • Aging
  • Alzheimer's disease
  • Cholinergic neuron
  • Development
  • Neuronal size
  • Striatum

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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