Human striatal cholinergic neurons in development, aging and Alzheimer's disease

Changiz Geula; Hajime Tokuno; Louis Hersh; M. -Marsel Mesulam

doi:10.1016/0006-8993(90)90414-7

Human striatal cholinergic neurons in development, aging and Alzheimer's disease

Changiz Geula^*, Hajime Tokuno, Louis Hersh, M. -Marsel Mesulam

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

The cross-sectional area of cholinergic neurons stained immunohistochemically for choline acetyltransferase were measured in the striatum of infants, young adults, aged individuals and patients with Alzheimer's disease. Cholinergic neurons were distributed throughout the caudate nucleus and the putamen and displayed no significant variations in size across the two structures. The cross-sectional area of striatal cholinergic neurons was smaller in infants as compared with all the other groups examined. No significant changes were observed in the size of these neurons as a consequence of aging or Alzheimer's disease.

Original language	English (US)
Pages (from-to)	310-312
Number of pages	3
Journal	Brain research
Volume	508
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(90)90414-7
State	Published - Feb 5 1990

Keywords

Aging
Alzheimer's disease
Cholinergic neuron
Development
Neuronal size
Striatum

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

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title = "Human striatal cholinergic neurons in development, aging and Alzheimer's disease",

abstract = "The cross-sectional area of cholinergic neurons stained immunohistochemically for choline acetyltransferase were measured in the striatum of infants, young adults, aged individuals and patients with Alzheimer's disease. Cholinergic neurons were distributed throughout the caudate nucleus and the putamen and displayed no significant variations in size across the two structures. The cross-sectional area of striatal cholinergic neurons was smaller in infants as compared with all the other groups examined. No significant changes were observed in the size of these neurons as a consequence of aging or Alzheimer's disease.",

keywords = "Aging, Alzheimer's disease, Cholinergic neuron, Development, Neuronal size, Striatum",

author = "Changiz Geula and Hajime Tokuno and Louis Hersh and {-Marsel Mesulam}, M.",

note = "Funding Information: We would like to thank Leah Christie and Kristin Loud for expert secretarial and technical assistance. We are grateful to Drs. Catherine Joachim, Bruce Price and William Schoene for providing human brain tissue. Supported in part by an NRSA award (AG05455), an Alzheimer's Disease Research Center Grant (AG05134), the Alzheimer's Disease and Related Disorders Association and by a Javits Neuroscience Investigator Award (NS20285).",

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doi = "10.1016/0006-8993(90)90414-7",

language = "English (US)",

volume = "508",

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T1 - Human striatal cholinergic neurons in development, aging and Alzheimer's disease

AU - Geula, Changiz

AU - Tokuno, Hajime

AU - Hersh, Louis

AU - -Marsel Mesulam, M.

N1 - Funding Information: We would like to thank Leah Christie and Kristin Loud for expert secretarial and technical assistance. We are grateful to Drs. Catherine Joachim, Bruce Price and William Schoene for providing human brain tissue. Supported in part by an NRSA award (AG05455), an Alzheimer's Disease Research Center Grant (AG05134), the Alzheimer's Disease and Related Disorders Association and by a Javits Neuroscience Investigator Award (NS20285).

PY - 1990/2/5

Y1 - 1990/2/5

N2 - The cross-sectional area of cholinergic neurons stained immunohistochemically for choline acetyltransferase were measured in the striatum of infants, young adults, aged individuals and patients with Alzheimer's disease. Cholinergic neurons were distributed throughout the caudate nucleus and the putamen and displayed no significant variations in size across the two structures. The cross-sectional area of striatal cholinergic neurons was smaller in infants as compared with all the other groups examined. No significant changes were observed in the size of these neurons as a consequence of aging or Alzheimer's disease.

AB - The cross-sectional area of cholinergic neurons stained immunohistochemically for choline acetyltransferase were measured in the striatum of infants, young adults, aged individuals and patients with Alzheimer's disease. Cholinergic neurons were distributed throughout the caudate nucleus and the putamen and displayed no significant variations in size across the two structures. The cross-sectional area of striatal cholinergic neurons was smaller in infants as compared with all the other groups examined. No significant changes were observed in the size of these neurons as a consequence of aging or Alzheimer's disease.

KW - Aging

KW - Alzheimer's disease

KW - Cholinergic neuron

KW - Development

KW - Neuronal size

KW - Striatum

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JO - Brain Research

JF - Brain Research

SN - 0006-8993

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Human striatal cholinergic neurons in development, aging and Alzheimer's disease

Abstract

Keywords

ASJC Scopus subject areas

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