Human striatum: the distribution of neurofibrillary tangles in Alzheimer's disease

N. Selden; M. M. Mesulam; C. Geula

doi:10.1016/0006-8993(94)91136-3

Human striatum: the distribution of neurofibrillary tangles in Alzheimer's disease

N. Selden, M. M. Mesulam, C. Geula^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

Abstract

The distribution of neurofibrillary tangles and senile plaques was surveyed in the striatum of Alzheimer's disease cases. Neurofibrillary tangles were present throughout the striatum, but displayerd significantly higher densities in the nucleus accumbens, olfactory tubercle and tail of the caudate nucleus. Senile plaques with dense amyloid cores showed a similar pattern of distribution. By contrast, non-cored senile plaques were homogenously distributed in all striatal territories. No tangles and few plaques were observed in the striatum of control cases. These findings suggest that the 'limbic' striatum is preferentially vulnerable to pathology in Alzheimer's disease.

Original language	English (US)
Pages (from-to)	327-331
Number of pages	5
Journal	Brain research
Volume	648
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(94)91136-3
State	Published - Jun 20 1994

Keywords

Alzheimer's disease
Limbic system
Plaque
Striatum
Tangle
Ventral straitum

ASJC Scopus subject areas

Clinical Neurology
Molecular Biology
General Neuroscience
Developmental Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/0006-8993(94)91136-3

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@article{afda92ea52b6428abbeb5205af7cd546,

title = "Human striatum: the distribution of neurofibrillary tangles in Alzheimer's disease",

abstract = "The distribution of neurofibrillary tangles and senile plaques was surveyed in the striatum of Alzheimer's disease cases. Neurofibrillary tangles were present throughout the striatum, but displayerd significantly higher densities in the nucleus accumbens, olfactory tubercle and tail of the caudate nucleus. Senile plaques with dense amyloid cores showed a similar pattern of distribution. By contrast, non-cored senile plaques were homogenously distributed in all striatal territories. No tangles and few plaques were observed in the striatum of control cases. These findings suggest that the 'limbic' striatum is preferentially vulnerable to pathology in Alzheimer's disease.",

keywords = "Alzheimer's disease, Limbic system, Plaque, Striatum, Tangle, Ventral straitum",

author = "N. Selden and Mesulam, {M. M.} and C. Geula",

note = "Funding Information: We thank L. Christie, K. Bouve and T. Calabrese for expert secretarial and technical support. This work was supported in part by grants from the American Federation for Aging Research, the National Institute on Aging (AG10282), a Javits Neuroscience Investigator Award (NS20285) and an Alzheimer's Research Center Grant (AG05134). N.S. was supported by an American Federation for Aging Research/Hartford Foundation Scholarship.",

year = "1994",

month = jun,

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doi = "10.1016/0006-8993(94)91136-3",

language = "English (US)",

volume = "648",

pages = "327--331",

journal = "Brain research",

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T2 - the distribution of neurofibrillary tangles in Alzheimer's disease

AU - Selden, N.

AU - Mesulam, M. M.

AU - Geula, C.

N1 - Funding Information: We thank L. Christie, K. Bouve and T. Calabrese for expert secretarial and technical support. This work was supported in part by grants from the American Federation for Aging Research, the National Institute on Aging (AG10282), a Javits Neuroscience Investigator Award (NS20285) and an Alzheimer's Research Center Grant (AG05134). N.S. was supported by an American Federation for Aging Research/Hartford Foundation Scholarship.

PY - 1994/6/20

Y1 - 1994/6/20

N2 - The distribution of neurofibrillary tangles and senile plaques was surveyed in the striatum of Alzheimer's disease cases. Neurofibrillary tangles were present throughout the striatum, but displayerd significantly higher densities in the nucleus accumbens, olfactory tubercle and tail of the caudate nucleus. Senile plaques with dense amyloid cores showed a similar pattern of distribution. By contrast, non-cored senile plaques were homogenously distributed in all striatal territories. No tangles and few plaques were observed in the striatum of control cases. These findings suggest that the 'limbic' striatum is preferentially vulnerable to pathology in Alzheimer's disease.

AB - The distribution of neurofibrillary tangles and senile plaques was surveyed in the striatum of Alzheimer's disease cases. Neurofibrillary tangles were present throughout the striatum, but displayerd significantly higher densities in the nucleus accumbens, olfactory tubercle and tail of the caudate nucleus. Senile plaques with dense amyloid cores showed a similar pattern of distribution. By contrast, non-cored senile plaques were homogenously distributed in all striatal territories. No tangles and few plaques were observed in the striatum of control cases. These findings suggest that the 'limbic' striatum is preferentially vulnerable to pathology in Alzheimer's disease.

KW - Alzheimer's disease

KW - Limbic system

KW - Plaque

KW - Striatum

KW - Tangle

KW - Ventral straitum

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JO - Brain research

JF - Brain research

IS - 2

ER -

Human striatum: the distribution of neurofibrillary tangles in Alzheimer's disease

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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