Human striatum: the distribution of neurofibrillary tangles in Alzheimer's disease

N. Selden, M. M. Mesulam, C. Geula*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

42 Scopus citations


The distribution of neurofibrillary tangles and senile plaques was surveyed in the striatum of Alzheimer's disease cases. Neurofibrillary tangles were present throughout the striatum, but displayerd significantly higher densities in the nucleus accumbens, olfactory tubercle and tail of the caudate nucleus. Senile plaques with dense amyloid cores showed a similar pattern of distribution. By contrast, non-cored senile plaques were homogenously distributed in all striatal territories. No tangles and few plaques were observed in the striatum of control cases. These findings suggest that the 'limbic' striatum is preferentially vulnerable to pathology in Alzheimer's disease.

Original languageEnglish (US)
Pages (from-to)327-331
Number of pages5
JournalBrain research
Issue number2
StatePublished - Jun 20 1994


  • Alzheimer's disease
  • Limbic system
  • Plaque
  • Striatum
  • Tangle
  • Ventral straitum

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology


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