Human testis cdnas identified by sera from infertile patients: A molecular biological approach to immunocontraceptive development

Z. G. Liang, P. A. O’Hem, B. Yavetz, H. Yavetz, E. Goldberg

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

Sera from patients with known or suspected immunological infertility were used to screen a human testis cDNA library. A total of 59 sera detected 38 unique cDNA inserts of which four were testis specific by Northern blot analyses. One of these is a testis-specific isoform of calpastatin. Five additional clones, although not testis specific, were found to be testis abundant. The number and type of clones identified by these human sera suggests a possible aetiology for immunologic infertility. The testis-specific clones will be further characterized to establish their usefulness as contraceptive vaccine candidates.

Original languageEnglish (US)
Pages (from-to)297-305
Number of pages9
JournalReproduction, Fertility and Development
Volume6
Issue number3
DOIs
StatePublished - Jan 1 1994

ASJC Scopus subject areas

  • Biotechnology
  • Reproductive Medicine
  • Animal Science and Zoology
  • Molecular Biology
  • Genetics
  • Endocrinology
  • Developmental Biology

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