@article{bba57fdb96cb4c3089fde01026445b41,
title = "Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation",
abstract = "TH17 lymphocytes appear to be essential in the pathogenesis of numerous inflammatory diseases. We demonstrate here the expression of IL-17 and IL-22 receptors on blood-brain barrier endothelial cells (BBB-ECs) in multiple sclerosis lesions, and show that IL-17 and IL-22 disrupt BBB tight junctions in vitro and in vivo. Furthermore, TH17 lymphocytes transmigrate efficiently across BBB-ECs, highly express granzyme B, kill human neurons and promote central nervous system inflammation through CD4+ lymphocyte recruitment.",
author = "Hania Kebir and Katharina Kreymborg and Igal Ifergan and Aurore Dodelet-Devillers and Romain Cayrol and Monique Bernard and Fabrizio Giuliani and Nathalie Arbour and Burkhard Becher and Alexandre Prat",
note = "Funding Information: This study was supported by funding from the Multiple Sclerosis Society of Canada (MSSC) and from the Canadian Fund for Innovation to A.P. The animal studies were supported through grants from the US National MS Society and the Swiss National Science Foundation (B.B.). H.K., I.I., A.D.-D. and R.C. hold studentships from the MSSC and the Canadian Institutes of Health Research (CIHR)/Strategic Training Initiative in Health Research Neuroinflammation Training Program. K.K. has a fellowship from the Center for Neurosciences in Zurich. N.A. holds a CIHR Senior Research Fellowship Phase 2. B.B. is a Neuroscience Scholar of the US National MS Society. A.P. is a Research Scholar from the Fonds de la Recherche en Sant{\'e} du Qu{\'e}bec, and holds the Donald Paty Career Award of the MSSC. We thank I. Gutcher, S. Haak, D. Pasichnyk and J. Lagani{\`e}re for their excellent technical assistance. We are grateful to V.K. Kuchroo (Harvard Medical School), who kindly provided the 2D2 mice, and to J.P. Antel (McGill University) for providing assistance and human tissue.",
year = "2007",
month = oct,
doi = "10.1038/nm1651",
language = "English (US)",
volume = "13",
pages = "1173--1175",
journal = "Nature Medicine",
issn = "1078-8956",
publisher = "Nature Research",
number = "10",
}
