Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation

Hania Kebir, Katharina Kreymborg, Igal Ifergan, Aurore Dodelet-Devillers, Romain Cayrol, Monique Bernard, Fabrizio Giuliani, Nathalie Arbour, Burkhard Becher, Alexandre Prat*

*Corresponding author for this work

Research output: Contribution to journalArticle

1011 Scopus citations

Abstract

TH17 lymphocytes appear to be essential in the pathogenesis of numerous inflammatory diseases. We demonstrate here the expression of IL-17 and IL-22 receptors on blood-brain barrier endothelial cells (BBB-ECs) in multiple sclerosis lesions, and show that IL-17 and IL-22 disrupt BBB tight junctions in vitro and in vivo. Furthermore, TH17 lymphocytes transmigrate efficiently across BBB-ECs, highly express granzyme B, kill human neurons and promote central nervous system inflammation through CD4+ lymphocyte recruitment.

Original languageEnglish (US)
Pages (from-to)1173-1175
Number of pages3
JournalNature Medicine
Volume13
Issue number10
DOIs
StatePublished - Oct 1 2007

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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    Kebir, H., Kreymborg, K., Ifergan, I., Dodelet-Devillers, A., Cayrol, R., Bernard, M., Giuliani, F., Arbour, N., Becher, B., & Prat, A. (2007). Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation. Nature Medicine, 13(10), 1173-1175. https://doi.org/10.1038/nm1651