Human urinary bladder regeneration through tissue engineering - An analysis of 131 clinical cases

Marta Pokrywczynska*, Jan Adamowicz, Arun K. Sharma, Tomasz Drewa

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

56 Scopus citations


Replacement of urinary bladder tissue with functional equivalents remains one of the most challenging problems of reconstructive urology over the last several decades. The gold standard treatment for urinary diversion after radical cystectomy is the ileal conduit or neobladder; however, this technique is associated with numerous complications including electrolyte imbalances, mucus production, and the potential for malignant transformation. Tissue engineering techniques provide the impetus to construct functional bladder substitutes de novo. Within this review, we have thoroughly perused the literature utilizing PubMed in order to identify clinical studies involving bladder reconstruction utilizing tissue engineering methodologies. The idea of urinary bladder regeneration through tissue engineering dates back to the 1950s. Many natural and synthetic biomaterials such as plastic mold, gelatin sponge, Japanese paper, preserved dog bladder, lyophilized human dura, bovine pericardium, small intestinal submucosa, bladder acellular matrix, or composite of collagen and polyglycolic acid were used for urinary bladder regeneration with a wide range of outcomes. Recent progress in the tissue engineering field suggest that in vitro engineered bladder wall substitutes may have expanded clinical applicability in near future but preclinical investigations on large animal models with defective bladders are necessary to optimize the methods of bladder reconstruction by tissue engineering in humans.

Original languageEnglish (US)
Pages (from-to)264-271
Number of pages8
JournalExperimental Biology and Medicine
Issue number3
StatePublished - Mar 2014


  • Clinical research
  • reconstruction
  • regeneration
  • tissue engineering
  • urinary bladder

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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