Humanized Mice for Modeling Human Infectious Disease: Challenges, Progress, and Outlook

Nicolas Legrand; Alexander Ploss; Rudi Balling; Pablo D. Becker; Chiara Borsotti; Nicolas Brezillon; Jennifer Debarry; Ype de Jong; Hongkui Deng; James P. Di Santo; Stephanie Eisenbarth; Elizabeth Eynon; Richard A. Flavell; Carlos A. Guzman; Nicholas D. Huntington; Dina Kremsdorf; Michael P. Manns; Markus G. Manz; Jean Jacques Mention; Michael Ott; Chozhavendan Rathinam; Charles M. Rice; Anthony Rongvaux; Sean Stevens; Hergen Spits; Hélène Strick-Marchand; Hitoshi Takizawa; Anja U. van Lent; Chengyan Wang; Kees Weijer; Tim Willinger; Patrick Ziegler

doi:10.1016/j.chom.2009.06.006

Humanized Mice for Modeling Human Infectious Disease: Challenges, Progress, and Outlook

Nicolas Legrand, Alexander Ploss, Rudi Balling, Pablo D. Becker, Chiara Borsotti, Nicolas Brezillon, Jennifer Debarry, Ype de Jong, Hongkui Deng, James P. Di Santo^*, Stephanie Eisenbarth, Elizabeth Eynon, Richard A. Flavell, Carlos A. Guzman, Nicholas D. Huntington, Dina Kremsdorf, Michael P. Manns, Markus G. Manz, Jean Jacques Mention, Michael OttChozhavendan Rathinam, Charles M. Rice, Anthony Rongvaux, Sean Stevens, Hergen Spits, Hélène Strick-Marchand, Hitoshi Takizawa, Anja U. van Lent, Chengyan Wang, Kees Weijer, Tim Willinger, Patrick Ziegler

^*Corresponding author for this work

Research output: Contribution to journal › Short survey › peer-review

184 Scopus citations

Abstract

Over 800 million people worldwide are infected with hepatitis viruses, human immunodeficiency virus (HIV), and malaria, resulting in more than 5 million deaths annually. Here we discuss the potential and challenges of humanized mouse models for developing effective and affordable therapies and vaccines, which are desperately needed to combat these diseases.

Original language	English (US)
Pages (from-to)	5-9
Number of pages	5
Journal	Cell Host and Microbe
Volume	6
Issue number	1
DOIs	https://doi.org/10.1016/j.chom.2009.06.006
State	Published - Jul 23 2009
Externally published	Yes

Funding

The authors would like to thank Dr. Catherine Murray (Rockefeller University) for editing the manuscript. This work was supported by grants from the Gates Foundation through the Grand Challenges in Global Health initiative (to all authors). We are particularly indebted to Dr. Fil Randazzo (Gates Foundation) for his continued support and for motivating us to form a truly interdisciplinary team. C.M.R. is funded in part by the Greenberg Medical Research Institute, the Ellison Medical Foundation, the Starr Foundation, the Ronald A. Shellow Memorial Fund, and the Richard Salomon Family Foundation. C.M.R. is an Ellison Medical Foundation Senior Scholar in Global Infectious Diseases. R.A.F. is an Investigator of the Howard Hughes Medical Institute. A.P. was supported by Kimberly Lawrence-Netter Cancer Research Discovery Fund Award Postdoctoral Fellowship. J.P.D. is supported by institutional grants from the Institut Pasteur and Inserm. H.D. is supported by a major science and technology project of China for the prevention and treatment of major infectious diseases. S.S. was an employee of Regeneron Pharmaceuticals, and H.S. was an employee of Genentech at the time this work was performed.

ASJC Scopus subject areas

Virology
Parasitology
Microbiology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.chom.2009.06.006

Cite this

Legrand, N., Ploss, A., Balling, R., Becker, P. D., Borsotti, C., Brezillon, N., Debarry, J., de Jong, Y., Deng, H., Di Santo, J. P., Eisenbarth, S., Eynon, E., Flavell, R. A., Guzman, C. A., Huntington, N. D., Kremsdorf, D., Manns, M. P., Manz, M. G., Mention, J. J., ... Ziegler, P. (2009). Humanized Mice for Modeling Human Infectious Disease: Challenges, Progress, and Outlook. Cell Host and Microbe, 6(1), 5-9. https://doi.org/10.1016/j.chom.2009.06.006

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abstract = "Over 800 million people worldwide are infected with hepatitis viruses, human immunodeficiency virus (HIV), and malaria, resulting in more than 5 million deaths annually. Here we discuss the potential and challenges of humanized mouse models for developing effective and affordable therapies and vaccines, which are desperately needed to combat these diseases.",

author = "Nicolas Legrand and Alexander Ploss and Rudi Balling and Becker, {Pablo D.} and Chiara Borsotti and Nicolas Brezillon and Jennifer Debarry and {de Jong}, Ype and Hongkui Deng and {Di Santo}, {James P.} and Stephanie Eisenbarth and Elizabeth Eynon and Flavell, {Richard A.} and Guzman, {Carlos A.} and Huntington, {Nicholas D.} and Dina Kremsdorf and Manns, {Michael P.} and Manz, {Markus G.} and Mention, {Jean Jacques} and Michael Ott and Chozhavendan Rathinam and Rice, {Charles M.} and Anthony Rongvaux and Sean Stevens and Hergen Spits and H{\'e}l{\`e}ne Strick-Marchand and Hitoshi Takizawa and {van Lent}, {Anja U.} and Chengyan Wang and Kees Weijer and Tim Willinger and Patrick Ziegler",

note = "Funding Information: The authors would like to thank Dr. Catherine Murray (Rockefeller University) for editing the manuscript. This work was supported by grants from the Gates Foundation through the Grand Challenges in Global Health initiative (to all authors). We are particularly indebted to Dr. Fil Randazzo (Gates Foundation) for his continued support and for motivating us to form a truly interdisciplinary team. C.M.R. is funded in part by the Greenberg Medical Research Institute, the Ellison Medical Foundation, the Starr Foundation, the Ronald A. Shellow Memorial Fund, and the Richard Salomon Family Foundation. C.M.R. is an Ellison Medical Foundation Senior Scholar in Global Infectious Diseases. R.A.F. is an Investigator of the Howard Hughes Medical Institute. A.P. was supported by Kimberly Lawrence-Netter Cancer Research Discovery Fund Award Postdoctoral Fellowship. J.P.D. is supported by institutional grants from the Institut Pasteur and Inserm. H.D. is supported by a major science and technology project of China for the prevention and treatment of major infectious diseases. S.S. was an employee of Regeneron Pharmaceuticals, and H.S. was an employee of Genentech at the time this work was performed.",

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Legrand, N, Ploss, A, Balling, R, Becker, PD, Borsotti, C, Brezillon, N, Debarry, J, de Jong, Y, Deng, H, Di Santo, JP, Eisenbarth, S, Eynon, E, Flavell, RA, Guzman, CA, Huntington, ND, Kremsdorf, D, Manns, MP, Manz, MG, Mention, JJ, Ott, M, Rathinam, C, Rice, CM, Rongvaux, A, Stevens, S, Spits, H, Strick-Marchand, H, Takizawa, H, van Lent, AU, Wang, C, Weijer, K, Willinger, T & Ziegler, P 2009, 'Humanized Mice for Modeling Human Infectious Disease: Challenges, Progress, and Outlook', Cell Host and Microbe, vol. 6, no. 1, pp. 5-9. https://doi.org/10.1016/j.chom.2009.06.006

TY - JOUR

T1 - Humanized Mice for Modeling Human Infectious Disease

T2 - Challenges, Progress, and Outlook

AU - Legrand, Nicolas

AU - Ploss, Alexander

AU - Balling, Rudi

AU - Becker, Pablo D.

AU - Borsotti, Chiara

AU - Brezillon, Nicolas

AU - Debarry, Jennifer

AU - de Jong, Ype

AU - Deng, Hongkui

AU - Di Santo, James P.

AU - Eisenbarth, Stephanie

AU - Eynon, Elizabeth

AU - Flavell, Richard A.

AU - Guzman, Carlos A.

AU - Huntington, Nicholas D.

AU - Kremsdorf, Dina

AU - Manns, Michael P.

AU - Manz, Markus G.

AU - Mention, Jean Jacques

AU - Ott, Michael

AU - Rathinam, Chozhavendan

AU - Rice, Charles M.

AU - Rongvaux, Anthony

AU - Stevens, Sean

AU - Spits, Hergen

AU - Strick-Marchand, Hélène

AU - Takizawa, Hitoshi

AU - van Lent, Anja U.

AU - Wang, Chengyan

AU - Weijer, Kees

AU - Willinger, Tim

AU - Ziegler, Patrick

N1 - Funding Information: The authors would like to thank Dr. Catherine Murray (Rockefeller University) for editing the manuscript. This work was supported by grants from the Gates Foundation through the Grand Challenges in Global Health initiative (to all authors). We are particularly indebted to Dr. Fil Randazzo (Gates Foundation) for his continued support and for motivating us to form a truly interdisciplinary team. C.M.R. is funded in part by the Greenberg Medical Research Institute, the Ellison Medical Foundation, the Starr Foundation, the Ronald A. Shellow Memorial Fund, and the Richard Salomon Family Foundation. C.M.R. is an Ellison Medical Foundation Senior Scholar in Global Infectious Diseases. R.A.F. is an Investigator of the Howard Hughes Medical Institute. A.P. was supported by Kimberly Lawrence-Netter Cancer Research Discovery Fund Award Postdoctoral Fellowship. J.P.D. is supported by institutional grants from the Institut Pasteur and Inserm. H.D. is supported by a major science and technology project of China for the prevention and treatment of major infectious diseases. S.S. was an employee of Regeneron Pharmaceuticals, and H.S. was an employee of Genentech at the time this work was performed.

PY - 2009/7/23

Y1 - 2009/7/23

N2 - Over 800 million people worldwide are infected with hepatitis viruses, human immunodeficiency virus (HIV), and malaria, resulting in more than 5 million deaths annually. Here we discuss the potential and challenges of humanized mouse models for developing effective and affordable therapies and vaccines, which are desperately needed to combat these diseases.

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Humanized Mice for Modeling Human Infectious Disease: Challenges, Progress, and Outlook

Abstract

Funding

ASJC Scopus subject areas

UN SDGs

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