Hunger selectively modulates corticolimbic activation to food stimuli in humans

Kevin S. LaBar*, Darren R. Gitelman, Todd B. Parrish, Yun Hee Kim, Anna C. Nobre, M. Marsel Mesulam

*Corresponding author for this work

Research output: Contribution to journalArticle

335 Scopus citations

Abstract

Functional magnetic resonance imaging (fMRI) was used to determine whether visual responses to food in the human amygdala and related corticolimbic structures would be selectively altered by changes in states of hunger. Participants viewed images of motivationally relevant (food) and motivationally irrelevant (tool) objects while undergoing fMRI in alternately hungry and satiated conditions. Food-related visual stimuli elicited greater responses in the amygdala, parahippocampal gyrus, and anterior fusiform gyms when participants were in a hungry state relative to a satiated state. The state-dependent activation of these brain structures did not generalize to the motivationally irrelevant objects. These results support the hypothesis that the amygdala and associated inferotemporal regions are involved in the integration of subjective interoceptive states with relevant sensory cues processed along the ventral visual stream.

Original languageEnglish (US)
Pages (from-to)493-500
Number of pages8
JournalBehavioral Neuroscience
Volume115
Issue number2
DOIs
StatePublished - 2001

ASJC Scopus subject areas

  • Behavioral Neuroscience

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