Huntington's disease: Underlying molecular mechanisms and emerging concepts

John Labbadia, Richard I. Morimoto*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

203 Scopus citations

Abstract

Huntington's disease (HD) is a progressive neurodegenerative disorder for which no disease modifying treatments exist. Many molecular changes and cellular consequences that underlie HD are observed in other neurological disorders, suggesting that common pathological mechanisms and pathways may exist. Recent findings have enhanced our understanding of the way cells regulate and respond to expanded polyglutamine proteins such as mutant huntingtin. These studies demonstrate that in addition to effects on folding, aggregation, and clearance pathways, a general transcriptional mechanism also dictates the expression of polyglutamine proteins. Here, we summarize the key pathways and networks that are important in HD in the context of recent therapeutic advances and highlight how their interplay may be of relevance to other protein folding disorders.

Original languageEnglish (US)
Pages (from-to)378-385
Number of pages8
JournalTrends in Biochemical Sciences
Volume38
Issue number8
DOIs
StatePublished - Aug 2013

Keywords

  • Huntington's disease
  • Molecular mechanisms
  • Therapeutic approaches

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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