Hyaline globules in renal cell carcinoma and hepatocellular carcinoma: A clue or a diagnostic pitfall on fine-needle aspiration?

Ritu Nayar*, Eleni Bourtsos, Denise V.S. DeFrias

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

The cytologic similarity to hepatocellular carcinoma (HCC) of 2 cases of granular renal cell carcinoma (RCC) with hyaline globules (HGs) prompted us to evaluate the frequency of HGs in RCC and HCC and the association between cell type, differentiation, and malignant potential of these 2 neoplasms and the presence of HGs. We studied fine-needle aspirates from 23 cases of RCC (primary, 7; metastatic, 16) and 23 cases of primary HCC and noted anatomic site, tumor cell type, and presence, quality, and quantity of HGs. Fuhrman nuclear grade was assigned to RCC and overall differentiation to HCC cases. RCC cell type was granular (7), mixed (4), and clear (12). HCC cases were granular (22) and clear (1). Morphologically similar, predominantly intracytoplasmic HGs were identified in 4 RCCs and 10 HCCs. All 4 RCCs with HGs were at metastatic sites, granular cell type, and high Fuhrman grade. HGs showed no association with differentiation of HCC. While HGs are seen more commonly in HCC than in RCC, their presence in an adenocarcinoma should bring renal origin into consideration. The presence of HGs in metastatic granular RCC, particularly in the liver, can lead to misinterpretation as primary HCC.

Original languageEnglish (US)
Pages (from-to)576-582
Number of pages7
JournalAmerican journal of clinical pathology
Volume114
Issue number4
DOIs
StatePublished - Oct 2000

Keywords

  • Fine-needle aspiration
  • Hepatocellurar carcinoma
  • Hyaline globules
  • Primary neoplastic site
  • Renal cell carcinoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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