Hyaluronan blocks oligodendrocyte progenitor maturation and remyelination through TLR2

J. A. Sloane, C. Batt, Y. Ma, Z. M. Harris, B. Trapp, T. Vartanian*

*Corresponding author for this work

Research output: Contribution to journalArticle

219 Scopus citations

Abstract

Failure of remyelination is largely responsible for sustained neurologic symptoms in multiple sclerosis (MS). MS lesions contain hyaluronan deposits that inhibit oligodendrocyte precursor cell (OPC) maturation. However, the mechanismbehind this inhibition is unclear. We report here that Toll-like receptor 2 (TLR2) is expressed by oligodendrocytes and is up-regulated in MS lesions. Pathogen-derived TLR2 agonists, but not agonists for other TLRs, inhibit OPC maturation in vitro. Hyaluronan-mediated inhibition of OPC maturation requires TLR2 and MyD88, a TLR2 adaptor molecule. Ablated expression of TLR2 also enhances remyelination in a lysolecithin animal model. Hyaluronidases expressed by OPCs degrade hyaluronan to hyaluronan oligomers, a requirement for hyaluronan/TLR2 signaling.MSlesions contain both TLR2 + oligodendrocytes and low-molecular-weight hyaluronan, consistent with their importance to remyelination in MS.Wethus have defined a mechanism controlling remyelination failure in MS where hyaluronan is degraded by hyaluronidases into hyaluronan oligomers that block OPC maturation and remyelination through TLR2-MyD88 signaling.

Original languageEnglish (US)
Pages (from-to)11555-11560
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume107
Issue number25
DOIs
StatePublished - Jun 22 2010

Keywords

  • Hyaluronidase
  • Innate immunity
  • MyD88

ASJC Scopus subject areas

  • General

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