Hyaluronan in the pericellular coat: An additional layer of complexity in early cell adhesion events

Miriam Cohen*, Derk Joester, Ilana Sabanay, Lia Addadi, Benjamin Geiger

*Corresponding author for this work

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Cell adhesion is a multistage process whereby specific surface receptors interact with the corresponding ligands on the extracellular matrix or on neighboring cells. These complex interactions involve a wide variety of cellular molecules including transmembrane and cytoskeletal components, scaffolding proteins, and a wide variety of signaling enzymes. In this article we discuss recent data characterizing the involvement of the pericellular hyaluronan coat in early stages of cell-matrix adhesion. In particular, we address the mechanisms underlying the transition from hyaluronan- to integrin-mediated adhesion, and the role of the actin cytoskeleton in the "inside-out" regulation and maintenance of the pericellular hyaluronan coat.

Original languageEnglish (US)
Pages (from-to)327-332
Number of pages6
JournalSoft Matter
Volume3
Issue number3
DOIs
StatePublished - Jan 1 2007

ASJC Scopus subject areas

  • Chemistry(all)
  • Condensed Matter Physics

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