Hybridization-induced "off-on" 19F-NMR signal probe release from DNA-functionalized gold nanoparticles

Alexander Kieger, Michael J. Wiester, Daniel Procissi, Todd B. Parrish, Chad A. Mirkin*, C. Shad Thaxton

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Fluorine-19-DNA-functionalized gold nanoparticles ( 19F-DNA AuNPs) are demonstrated to provide a 19F-NMR off-on switch in response to target-specific DNA hybridization events. AuNP-bound 19F-DNA produces a low intensity signal that is undetectable above background. Upon complementary DNA hybridization and subsequent 19F-DNA release, the 19F-NMR signal becomes detectable. This method has the potential to be used both in vitro and in vivo to non-invasively detect and image specific nucleic acid binding events of interest.

Original languageEnglish (US)
Pages (from-to)1977-1981
Number of pages5
JournalSmall
Volume7
Issue number14
DOIs
StatePublished - Jul 18 2011

Keywords

  • NMR spectroscopy
  • fluorine
  • gold nanoparticles
  • molecular recognition

ASJC Scopus subject areas

  • Biotechnology
  • Biomaterials
  • Chemistry(all)
  • Materials Science(all)

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