Hydrodynamics of aqueous humor outflow

M. Johnson*, D. Overby, J. Ruberti, T. F. Freddo, H. Gong

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We present a hydrodynamic model of the aqueous outflow pathway that can, for the first time, account for the generation of outflow resistance based upon anatomical measurements. The hydraulic conductivity of the extracellular matrix in the juxtacanalicular connective tissue (JCT) is determined by combining advanced morphometric techniques with electron microscopy images taken using quick-freeze/deep-etch to preserve ultrastructural detail. A hydrodynamic interaction between pores of the endothelium of Schlemm's canal, breaks in the basement membrane, and this morphometrically-determined hydraulic conductivity lead to predictions that are consistent with experimentally-measured outflow resistances.

Original languageEnglish (US)
Title of host publicationAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
PublisherIEEE
Number of pages1
ISBN (Print)0780356756
StatePublished - Dec 1 1999
EventProceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS) - Atlanta, GA, USA
Duration: Oct 13 1999Oct 16 1999

Publication series

NameAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume2
ISSN (Print)0589-1019

Other

OtherProceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS)
CityAtlanta, GA, USA
Period10/13/9910/16/99

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

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  • Cite this

    Johnson, M., Overby, D., Ruberti, J., Freddo, T. F., & Gong, H. (1999). Hydrodynamics of aqueous humor outflow. In Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings (Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings; Vol. 2). IEEE.