Hydrodynamics of aqueous humor outflow

M. Johnson*, D. Overby, J. Ruberti, T. F. Freddo, H. Gong

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We present a hydrodynamic model of the aqueous outflow pathway that can, for the first time, account for the generation of outflow resistance based upon anatomical measurements. The hydraulic conductivity of the extracellular matrix in the juxtacanalicular connective tissue (JCT) is determined by combining advanced morphometric techniques with electron microscopy images taken using quick-freeze/deep-etch to preserve ultrastructural detail. A hydrodynamic interaction between pores of the endothelium of Schlemm's canal, breaks in the basement membrane, and this morphometrically-determined hydraulic conductivity lead to predictions that are consistent with experimentally-measured outflow resistances.

Original languageEnglish (US)
Title of host publicationAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
PublisherIEEE
Number of pages1
Volume2
ISBN (Print)0780356756
StatePublished - Dec 1 1999
EventProceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS) - Atlanta, GA, USA
Duration: Oct 13 1999Oct 16 1999

Other

OtherProceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS)
CityAtlanta, GA, USA
Period10/13/9910/16/99

Fingerprint

Aqueous Humor
Hydraulic conductivity
Hydrodynamics
Canals
Basement Membrane
Connective Tissue
Electron microscopy
Endothelium
Extracellular Matrix
Electron Microscopy
Tissue

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

Cite this

Johnson, M., Overby, D., Ruberti, J., Freddo, T. F., & Gong, H. (1999). Hydrodynamics of aqueous humor outflow. In Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings (Vol. 2). IEEE.
Johnson, M. ; Overby, D. ; Ruberti, J. ; Freddo, T. F. ; Gong, H. / Hydrodynamics of aqueous humor outflow. Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. Vol. 2 IEEE, 1999.
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Johnson, M, Overby, D, Ruberti, J, Freddo, TF & Gong, H 1999, Hydrodynamics of aqueous humor outflow. in Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. vol. 2, IEEE, Proceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS), Atlanta, GA, USA, 10/13/99.

Hydrodynamics of aqueous humor outflow. / Johnson, M.; Overby, D.; Ruberti, J.; Freddo, T. F.; Gong, H.

Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. Vol. 2 IEEE, 1999.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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T1 - Hydrodynamics of aqueous humor outflow

AU - Johnson, M.

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AU - Ruberti, J.

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AU - Gong, H.

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N2 - We present a hydrodynamic model of the aqueous outflow pathway that can, for the first time, account for the generation of outflow resistance based upon anatomical measurements. The hydraulic conductivity of the extracellular matrix in the juxtacanalicular connective tissue (JCT) is determined by combining advanced morphometric techniques with electron microscopy images taken using quick-freeze/deep-etch to preserve ultrastructural detail. A hydrodynamic interaction between pores of the endothelium of Schlemm's canal, breaks in the basement membrane, and this morphometrically-determined hydraulic conductivity lead to predictions that are consistent with experimentally-measured outflow resistances.

AB - We present a hydrodynamic model of the aqueous outflow pathway that can, for the first time, account for the generation of outflow resistance based upon anatomical measurements. The hydraulic conductivity of the extracellular matrix in the juxtacanalicular connective tissue (JCT) is determined by combining advanced morphometric techniques with electron microscopy images taken using quick-freeze/deep-etch to preserve ultrastructural detail. A hydrodynamic interaction between pores of the endothelium of Schlemm's canal, breaks in the basement membrane, and this morphometrically-determined hydraulic conductivity lead to predictions that are consistent with experimentally-measured outflow resistances.

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Johnson M, Overby D, Ruberti J, Freddo TF, Gong H. Hydrodynamics of aqueous humor outflow. In Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. Vol. 2. IEEE. 1999