TY - GEN
T1 - Hydrodynamics of aqueous humor outflow
AU - Johnson, M.
AU - Overby, D.
AU - Ruberti, J.
AU - Freddo, T. F.
AU - Gong, H.
N1 - Copyright:
Copyright 2004 Elsevier Science B.V., Amsterdam. All rights reserved.
PY - 1999
Y1 - 1999
N2 - We present a hydrodynamic model of the aqueous outflow pathway that can, for the first time, account for the generation of outflow resistance based upon anatomical measurements. The hydraulic conductivity of the extracellular matrix in the juxtacanalicular connective tissue (JCT) is determined by combining advanced morphometric techniques with electron microscopy images taken using quick-freeze/deep-etch to preserve ultrastructural detail. A hydrodynamic interaction between pores of the endothelium of Schlemm's canal, breaks in the basement membrane, and this morphometrically-determined hydraulic conductivity lead to predictions that are consistent with experimentally-measured outflow resistances.
AB - We present a hydrodynamic model of the aqueous outflow pathway that can, for the first time, account for the generation of outflow resistance based upon anatomical measurements. The hydraulic conductivity of the extracellular matrix in the juxtacanalicular connective tissue (JCT) is determined by combining advanced morphometric techniques with electron microscopy images taken using quick-freeze/deep-etch to preserve ultrastructural detail. A hydrodynamic interaction between pores of the endothelium of Schlemm's canal, breaks in the basement membrane, and this morphometrically-determined hydraulic conductivity lead to predictions that are consistent with experimentally-measured outflow resistances.
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M3 - Conference contribution
AN - SCOPUS:0033313850
SN - 0780356756
T3 - Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
SP - 1316
BT - Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
PB - IEEE
T2 - Proceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS)
Y2 - 13 October 1999 through 16 October 1999
ER -