Hydrogen bonding in aprotic solvents, a new strategy for gelation of bioinspired catecholic copolymers with N-isopropylamide

Mohammad Vatankhah-Varnoosfaderani, Amin GhavamiNejad, Saud Hashmi, Florian J. Stadler

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

Copolymers of N-isopropylacrylamide (NIPAM) and dopamine methacrylate can establish a reversible, self-healing 3D network in aprotic solvents based on hydrogen bonding. The reactivity and hydrogen bonding formation of catechol groups in copolymer chains are studied by UV-vis and 1H NMR spectroscopy, while reversibility from sol to gel and inverse as well as self-healing properties are tested rheologically. The produced reversible organogel can self-encapsulate physically interacting or chemically bonded solutes such as drugs due to thermosensitivity of the used copolymer. This system offers dual-targeted and controlled drug delivery and release - by slowing down release kinetics by supramolecular bonding of the drug and by reducing diffusion rates due to modulus increase.

Original languageEnglish (US)
Pages (from-to)447-452
Number of pages6
JournalMacromolecular Rapid Communications
Volume36
Issue number5
DOIs
StatePublished - Mar 1 2015

Keywords

  • Catechol
  • Drug release
  • Hydrogen bonding
  • Mussel-inspired
  • Self-healing

ASJC Scopus subject areas

  • Polymers and Plastics
  • Organic Chemistry
  • Materials Chemistry

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