Hydrogen bonding in aprotic solvents, a new strategy for gelation of bioinspired catecholic copolymers with N-isopropylamide

Mohammad Vatankhah-Varnoosfaderani; Amin GhavamiNejad; Saud Hashmi; Florian J. Stadler

doi:10.1002/marc.201400501

Hydrogen bonding in aprotic solvents, a new strategy for gelation of bioinspired catecholic copolymers with N-isopropylamide

Mohammad Vatankhah-Varnoosfaderani, Amin GhavamiNejad, Saud Hashmi, Florian J. Stadler

Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

Copolymers of N-isopropylacrylamide (NIPAM) and dopamine methacrylate can establish a reversible, self-healing 3D network in aprotic solvents based on hydrogen bonding. The reactivity and hydrogen bonding formation of catechol groups in copolymer chains are studied by UV-vis and ¹H NMR spectroscopy, while reversibility from sol to gel and inverse as well as self-healing properties are tested rheologically. The produced reversible organogel can self-encapsulate physically interacting or chemically bonded solutes such as drugs due to thermosensitivity of the used copolymer. This system offers dual-targeted and controlled drug delivery and release - by slowing down release kinetics by supramolecular bonding of the drug and by reducing diffusion rates due to modulus increase.

Original language	English (US)
Pages (from-to)	447-452
Number of pages	6
Journal	Macromolecular Rapid Communications
Volume	36
Issue number	5
DOIs	https://doi.org/10.1002/marc.201400501
State	Published - Mar 1 2015

Keywords

Catechol
Drug release
Hydrogen bonding
Mussel-inspired
Self-healing

ASJC Scopus subject areas

Polymers and Plastics
Organic Chemistry
Materials Chemistry

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10.1002/marc.201400501

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title = "Hydrogen bonding in aprotic solvents, a new strategy for gelation of bioinspired catecholic copolymers with N-isopropylamide",

abstract = "Copolymers of N-isopropylacrylamide (NIPAM) and dopamine methacrylate can establish a reversible, self-healing 3D network in aprotic solvents based on hydrogen bonding. The reactivity and hydrogen bonding formation of catechol groups in copolymer chains are studied by UV-vis and 1H NMR spectroscopy, while reversibility from sol to gel and inverse as well as self-healing properties are tested rheologically. The produced reversible organogel can self-encapsulate physically interacting or chemically bonded solutes such as drugs due to thermosensitivity of the used copolymer. This system offers dual-targeted and controlled drug delivery and release - by slowing down release kinetics by supramolecular bonding of the drug and by reducing diffusion rates due to modulus increase.",

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AU - GhavamiNejad, Amin

AU - Hashmi, Saud

AU - Stadler, Florian J.

PY - 2015/3/1

Y1 - 2015/3/1

N2 - Copolymers of N-isopropylacrylamide (NIPAM) and dopamine methacrylate can establish a reversible, self-healing 3D network in aprotic solvents based on hydrogen bonding. The reactivity and hydrogen bonding formation of catechol groups in copolymer chains are studied by UV-vis and 1H NMR spectroscopy, while reversibility from sol to gel and inverse as well as self-healing properties are tested rheologically. The produced reversible organogel can self-encapsulate physically interacting or chemically bonded solutes such as drugs due to thermosensitivity of the used copolymer. This system offers dual-targeted and controlled drug delivery and release - by slowing down release kinetics by supramolecular bonding of the drug and by reducing diffusion rates due to modulus increase.

AB - Copolymers of N-isopropylacrylamide (NIPAM) and dopamine methacrylate can establish a reversible, self-healing 3D network in aprotic solvents based on hydrogen bonding. The reactivity and hydrogen bonding formation of catechol groups in copolymer chains are studied by UV-vis and 1H NMR spectroscopy, while reversibility from sol to gel and inverse as well as self-healing properties are tested rheologically. The produced reversible organogel can self-encapsulate physically interacting or chemically bonded solutes such as drugs due to thermosensitivity of the used copolymer. This system offers dual-targeted and controlled drug delivery and release - by slowing down release kinetics by supramolecular bonding of the drug and by reducing diffusion rates due to modulus increase.

KW - Catechol

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KW - Hydrogen bonding

KW - Mussel-inspired

KW - Self-healing

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Hydrogen bonding in aprotic solvents, a new strategy for gelation of bioinspired catecholic copolymers with N-isopropylamide

Abstract

Keywords

ASJC Scopus subject areas

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