Hydrophilic, Potent, and Selective 7-Substituted 2-Aminoquinolines as Improved Human Neuronal Nitric Oxide Synthase Inhibitors

Structure of human neuronal nitric oxide synthase heme domain in complex with 7-(((3-(5-Fluoropyridin-3-yl)propyl)amino)methyl)quinolin-2-amine

Pensa, A. V. (Contributor), Cinelli, M. A. (Contributor), Li, H. (Contributor), Chreifi, G. (Contributor), Mukherjee, P. (Contributor), Roman, L. J. (Contributor), Martásek, P. (Contributor), Poulos, T. L. (Contributor) & Silverman, R. B. (Contributor), Protein Data Bank (PDB), Aug 23 2017

DOI: 10.2210/pdb5VV2, https://www.wwpdb.org/pdb?id=pdb_00005vv2

Dataset

Structure of rat neuronal nitric oxide synthase heme domain in complex with 7-(((3-(Dimethylamino)benzyl)amino)methyl)quinolin-2-amine

Pensa, A. V. (Contributor), Cinelli, M. A. (Contributor), Li, H. (Contributor), Chreifi, G. (Contributor), Mukherjee, P. (Contributor), Roman, L. J. (Contributor), Martásek, P. (Contributor), Poulos, T. L. (Contributor) & Silverman, R. B. (Contributor), Protein Data Bank (PDB), Aug 16 2017

DOI: 10.2210/pdb5VUJ, https://www.wwpdb.org/pdb?id=pdb_00005vuj

Dataset

Structure of rat neuronal nitric oxide synthase heme domain in complex with 4-(2-(((2-Aminoquinolin-7-yl)methyl)amino)ethyl)-2-methylbenzonitrile

Pensa, A. V. (Contributor), Cinelli, M. A. (Contributor), Li, H. (Contributor), Chreifi, G. (Contributor), Mukherjee, P. (Contributor), Roman, L. J. (Contributor), Martásek, P. (Contributor), Poulos, T. L. (Contributor) & Silverman, R. B. (Contributor), Protein Data Bank (PDB), Aug 16 2017

DOI: 10.2210/pdb5VUR, https://www.wwpdb.org/pdb?id=pdb_00005vur

Dataset

Structure of human neuronal nitric oxide synthase heme domain in complex with 7-(((3-(4-Methoxypyridin-3-yl)propyl)amino)methyl)quinolin-2-amine

Pensa, A. V. (Contributor), Cinelli, M. A. (Contributor), Li, H. (Contributor), Chreifi, G. (Contributor), Mukherjee, P. (Contributor), Roman, L. J. (Contributor), Martásek, P. (Contributor), Poulos, T. L. (Contributor) & Silverman, R. B. (Contributor), Protein Data Bank (PDB), Aug 23 2017

DOI: 10.2210/pdb5VV1, https://www.wwpdb.org/pdb?id=pdb_00005vv1

Dataset

Structure of human neuronal nitric oxide synthase heme domain in complex with 7-(((3-(Pyridin-3-yl)propyl)amino)methyl)quinolin-2-amine

Pensa, A. V. (Contributor), Cinelli, M. A. (Contributor), Li, H. (Contributor), Chreifi, G. (Contributor), Mukherjee, P. (Contributor), Roman, L. J. (Contributor), Martásek, P. (Contributor), Poulos, T. L. (Contributor) & Silverman, R. B. (Contributor), Protein Data Bank (PDB), Aug 23 2017

DOI: 10.2210/pdb5VUZ, https://www.wwpdb.org/pdb?id=pdb_00005vuz

Dataset

Structure of human neuronal nitric oxide synthase heme domain in complex with 4-(2-(((2-Aminoquinolin-7-yl)methyl)amino)ethyl)benzonitrile

Pensa, A. V. (Contributor), Cinelli, M. A. (Contributor), Li, H. (Contributor), Chreifi, G. (Contributor), Mukherjee, P. (Contributor), Roman, L. J. (Contributor), Martásek, P. (Contributor), Poulos, T. L. (Contributor) & Silverman, R. B. (Contributor), Protein Data Bank (PDB), Aug 16 2017

DOI: 10.2210/pdb5VV3, https://www.wwpdb.org/pdb?id=pdb_00005vv3

Dataset

Structure of rat neuronal nitric oxide synthase heme domain in complex with 4-(2-(((2-Amino-4-methylquinolin-7-yl)methyl)amino)ethyl)benzonitrile

Pensa, A. V. (Contributor), Cinelli, M. A. (Contributor), Li, H. (Contributor), Chreifi, G. (Contributor), Mukherjee, P. (Contributor), Roman, L. J. (Contributor), Martásek, P. (Contributor), Poulos, T. L. (Contributor) & Silverman, R. B. (Contributor), Protein Data Bank (PDB), Aug 16 2017

DOI: 10.2210/pdb5VUT, https://www.wwpdb.org/pdb?id=pdb_00005vut

Dataset

Structure of human neuronal nitric oxide synthase heme domain in complex with 7-(((3-(Dimethylamino)benzyl)amino)methyl)quinolin-2-amine

Pensa, A. V. (Contributor), Cinelli, M. A. (Contributor), Li, H. (Contributor), Chreifi, G. (Contributor), Mukherjee, P. (Contributor), Roman, L. J. (Contributor), Martásek, P. (Contributor), Poulos, T. L. (Contributor) & Silverman, R. B. (Contributor), Protein Data Bank (PDB), Aug 23 2017

DOI: 10.2210/pdb5VUW, https://www.wwpdb.org/pdb?id=pdb_00005vuw

Dataset

Structure of rat neuronal nitric oxide synthase heme domain in complex with 7-(((3-Fluorophenyl)amino)methyl)quinolin-2-amine Dihydrochloride

Pensa, A. V. (Contributor), Cinelli, M. A. (Contributor), Li, H. (Contributor), Chreifi, G. (Contributor), Mukherjee, P. (Contributor), Roman, L. J. (Contributor), Martásek, P. (Contributor), Poulos, T. L. (Contributor) & Silverman, R. B. (Contributor), Protein Data Bank (PDB), Aug 16 2017

DOI: 10.2210/pdb5VUI, https://www.wwpdb.org/pdb?id=pdb_00005vui

Dataset

Structure of rat neuronal nitric oxide synthase heme domain in complex with 4-(2-(((2-Aminoquinolin-7-yl)methyl)amino)ethyl)benzonitrile

Pensa, A. V. (Contributor), Cinelli, M. A. (Contributor), Li, H. (Contributor), Chreifi, G. (Contributor), Mukherjee, P. (Contributor), Roman, L. J. (Contributor), Martásek, P. (Contributor), Poulos, T. L. (Contributor) & Silverman, R. B. (Contributor), Protein Data Bank (PDB), Aug 16 2017

DOI: 10.2210/pdb5VUQ, https://www.wwpdb.org/pdb?id=pdb_00005vuq

Dataset

Structure of rat neuronal nitric oxide synthase heme domain in complex with 7-(((3-(4-Methoxypyridin-3-yl)propyl)amino)methyl)quinolin-2-amine

Pensa, A. V. (Contributor), Cinelli, M. A. (Contributor), Li, H. (Contributor), Chreifi, G. (Contributor), Mukherjee, P. (Contributor), Roman, L. J. (Contributor), Martásek, P. (Contributor), Poulos, T. L. (Contributor) & Silverman, R. B. (Contributor), Protein Data Bank (PDB), Aug 16 2017

DOI: 10.2210/pdb5VUO, https://www.wwpdb.org/pdb?id=pdb_00005vuo

Dataset

Structure of bovine endothelial nitric oxide synthase heme domain in complex with 7-(((4-(Dimethylamino)phenethyl)amino)methyl)quinolin-2-amine

Pensa, A. V. (Contributor), Cinelli, M. A. (Contributor), Li, H. (Contributor), Chreifi, G. (Contributor), Mukherjee, P. (Contributor), Roman, L. J. (Contributor), Martásek, P. (Contributor), Poulos, T. L. (Contributor) & Silverman, R. B. (Contributor), Protein Data Bank (PDB), Aug 16 2017

DOI: 10.2210/pdb5VV6, https://www.wwpdb.org/pdb?id=pdb_00005vv6

Dataset

Structure of human endothelial nitric oxide synthase heme domain in complex with 4-(2-(((2-Amino-4-methylquinolin-7-yl)methyl)amino)ethyl)-2-methylbenzonitrile

Pensa, A. V. (Contributor), Cinelli, M. A. (Contributor), Li, H. (Contributor), Chreifi, G. (Contributor), Mukherjee, P. (Contributor), Roman, L. J. (Contributor), Martásek, P. (Contributor), Poulos, T. L. (Contributor) & Silverman, R. B. (Contributor), Protein Data Bank (PDB), Aug 16 2017

DOI: 10.2210/pdb5VVC, https://www.wwpdb.org/pdb?id=pdb_00005vvc

Dataset

Structure of human neuronal nitric oxide synthase heme domain in complex with 7-(((3-(4-Methylpyridin-3-yl)propyl)amino)methyl)quinolin-2-amine

Pensa, A. V. (Contributor), Cinelli, M. A. (Contributor), Li, H. (Contributor), Chreifi, G. (Contributor), Mukherjee, P. (Contributor), Roman, L. J. (Contributor), Martásek, P. (Contributor), Poulos, T. L. (Contributor) & Silverman, R. B. (Contributor), Protein Data Bank (PDB), Aug 16 2017

DOI: 10.2210/pdb5VV0, https://www.wwpdb.org/pdb?id=pdb_00005vv0

Dataset

Structure of bovine endothelial nitric oxide synthase heme domain in complex with 7-(((3-(Pyridin-3-yl)propyl)amino)methyl)quinolin-2-amine

Pensa, A. V. (Contributor), Cinelli, M. A. (Contributor), Li, H. (Contributor), Chreifi, G. (Contributor), Mukherjee, P. (Contributor), Roman, L. J. (Contributor), Martásek, P. (Contributor), Poulos, T. L. (Contributor) & Silverman, R. B. (Contributor), Protein Data Bank (PDB), Aug 16 2017

DOI: 10.2210/pdb5VV7, https://www.wwpdb.org/pdb?id=pdb_00005vv7

Dataset

Structure of bovine endothelial nitric oxide synthase heme domain in complex with 4-(2-(((2-Amino-4-methylquinolin-7-yl)methyl)amino)ethyl)-2-methylbenzonitrile

Pensa, A. V. (Contributor), Cinelli, M. A. (Contributor), Li, H. (Contributor), Chreifi, G. (Contributor), Mukherjee, P. (Contributor), Roman, L. J. (Contributor), Martásek, P. (Contributor), Poulos, T. L. (Contributor) & Silverman, R. B. (Contributor), Protein Data Bank (PDB), Aug 16 2017

DOI: 10.2210/pdb5VVA, https://www.wwpdb.org/pdb?id=pdb_00005vva

Dataset

Structure of bovine endothelial nitric oxide synthase heme domain in complex with 4-(2-(((2-Aminoquinolin-7-yl)methyl)amino)ethyl)benzonitrile

Pensa, A. V. (Contributor), Cinelli, M. A. (Contributor), Li, H. (Contributor), Chreifi, G. (Contributor), Mukherjee, P. (Contributor), Roman, L. J. (Contributor), Martásek, P. (Contributor), Poulos, T. L. (Contributor) & Silverman, R. B. (Contributor), Protein Data Bank (PDB), Aug 16 2017

DOI: 10.2210/pdb5VVN, https://www.wwpdb.org/pdb?id=pdb_00005vvn

Dataset

Structure of human neuronal nitric oxide synthase heme domain in complex with 7-(((3-Fluorophenyl)amino)methyl)quinolin-2-amine Dihydrochloride

Pensa, A. V. (Contributor), Cinelli, M. A. (Contributor), Li, H. (Contributor), Chreifi, G. (Contributor), Mukherjee, P. (Contributor), Roman, L. J. (Contributor), Martásek, P. (Contributor), Poulos, T. L. (Contributor) & Silverman, R. B. (Contributor), Protein Data Bank (PDB), Aug 23 2017

DOI: 10.2210/pdb5VUV, https://www.wwpdb.org/pdb?id=pdb_00005vuv

Dataset

Structure of human endothelial nitric oxide synthase heme domain in complex with 4-(2-(((2-Amino-4-methylquinolin-7-yl)methyl)amino)ethyl)benzonitrile

Pensa, A. V. (Contributor), Cinelli, M. A. (Contributor), Li, H. (Contributor), Chreifi, G. (Contributor), Mukherjee, P. (Contributor), Roman, L. J. (Contributor), Martásek, P. (Contributor), Poulos, T. L. (Contributor) & Silverman, R. B. (Contributor), Protein Data Bank (PDB), Aug 16 2017

DOI: 10.2210/pdb5VVD, https://www.wwpdb.org/pdb?id=pdb_00005vvd

Dataset

Structure of rat neuronal nitric oxide synthase heme domain in complex with 4-(2-(((2-Aminoquinolin-7-yl)methyl)amino)ethyl)-2-chlorobenzonitrile

Pensa, A. V. (Contributor), Cinelli, M. A. (Contributor), Li, H. (Contributor), Chreifi, G. (Contributor), Mukherjee, P. (Contributor), Roman, L. J. (Contributor), Martásek, P. (Contributor), Poulos, T. L. (Contributor) & Silverman, R. B. (Contributor), Protein Data Bank (PDB), Aug 16 2017

DOI: 10.2210/pdb5VUS, https://www.wwpdb.org/pdb?id=pdb_00005vus

Dataset

Structure of bovine endothelial nitric oxide synthase heme domain in complex with 4-(2-(((2-Aminoquinolin-7-yl)methyl)amino)ethyl)-2-chlorobenzonitrile

Pensa, A. V. (Contributor), Cinelli, M. A. (Contributor), Li, H. (Contributor), Chreifi, G. (Contributor), Mukherjee, P. (Contributor), Roman, L. J. (Contributor), Martásek, P. (Contributor), Poulos, T. L. (Contributor) & Silverman, R. B. (Contributor), Protein Data Bank (PDB), Aug 16 2017

DOI: 10.2210/pdb5VVG, https://www.wwpdb.org/pdb?id=pdb_00005vvg

Dataset

Structure of human neuronal nitric oxide synthase heme domain in complex with 7-(((4-(Dimethylamino)benzyl)amino)methyl)quinolin-2-amine

Pensa, A. V. (Contributor), Cinelli, M. A. (Contributor), Li, H. (Contributor), Chreifi, G. (Contributor), Mukherjee, P. (Contributor), Roman, L. J. (Contributor), Martásek, P. (Contributor), Poulos, T. L. (Contributor) & Silverman, R. B. (Contributor), Protein Data Bank (PDB), Aug 23 2017

DOI: 10.2210/pdb5VUX, https://www.wwpdb.org/pdb?id=pdb_00005vux

Dataset

Structure of human neuronal nitric oxide synthase heme domain in complex with 4-(2-(((2-Amino-4-methylquinolin-7-yl)methyl)amino)ethyl)-2-methylbenzonitrile

Pensa, A. V. (Contributor), Cinelli, M. A. (Contributor), Li, H. (Contributor), Chreifi, G. (Contributor), Mukherjee, P. (Contributor), Roman, L. J. (Contributor), Martásek, P. (Contributor), Poulos, T. L. (Contributor) & Silverman, R. B. (Contributor), Protein Data Bank (PDB), Aug 16 2017

DOI: 10.2210/pdb5VV5, https://www.wwpdb.org/pdb?id=pdb_00005vv5

Dataset

Structure of rat neuronal nitric oxide synthase heme domain in complex with 7-(((3-(Pyridin-3-yl)propyl)amino)methyl)quinolin-2-amine

Pensa, A. V. (Contributor), Cinelli, M. A. (Contributor), Li, H. (Contributor), Chreifi, G. (Contributor), Mukherjee, P. (Contributor), Roman, L. J. (Contributor), Martásek, P. (Contributor), Poulos, T. L. (Contributor) & Silverman, R. B. (Contributor), Protein Data Bank (PDB), Aug 16 2017

DOI: 10.2210/pdb5VUM, https://www.wwpdb.org/pdb?id=pdb_00005vum

Dataset

Structure of human endothelial nitric oxide synthase heme domain in complex with 4-(2-(((2-Aminoquinolin-7-yl)methyl)amino)ethyl)-2-methylbenzonitrile

Pensa, A. V. (Contributor), Cinelli, M. A. (Contributor), Li, H. (Contributor), Chreifi, G. (Contributor), Mukherjee, P. (Contributor), Roman, L. J. (Contributor), Martásek, P. (Contributor), Poulos, T. L. (Contributor) & Silverman, R. B. (Contributor), Protein Data Bank (PDB), Aug 16 2017

DOI: 10.2210/pdb5VVB, https://www.wwpdb.org/pdb?id=pdb_00005vvb

Dataset

Hydrophilic, Potent, and Selective 7-Substituted 2-Aminoquinolines as Improved Human Neuronal Nitric Oxide Synthase Inhibitors

Datasets

Search results