Hydroxynonenal adducts indicate a role for lipid peroxidation in neocortical and brainstem Lewy bodies in humans

Rudy J. Castellani; George Perry; Sandra L. Siedlak; Akihiko Nunomura; Shun Shimohama; Jing Zhang; Thomas Montine; Lawrence M. Sayre; Mark A. Smith

doi:10.1016/S0304-3940(01)02514-9

Hydroxynonenal adducts indicate a role for lipid peroxidation in neocortical and brainstem Lewy bodies in humans

Rudy J. Castellani, George Perry^*, Sandra L. Siedlak, Akihiko Nunomura, Shun Shimohama, Jing Zhang, Thomas Montine, Lawrence M. Sayre, Mark A. Smith

^*Corresponding author for this work

Pathology

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162 Scopus citations

Abstract

Multiple lines of evidence indicate that oxidative stress is a critical pathogenic factor in Parkinson disease (PD) and diffuse Lewy body disease (DLBD). Previously, we demonstrated increased levels of redox-active iron in Lewy bodies, and that Lewy bodies accumulate advanced glycation end-products. To further characterize the role of oxidative stress in diseases with Lewy body formation, we examined immunocytochemically eight cases of PD and five cases of DLBD for adducts of the lipid peroxidation adduct 4-hydroxy-2-nonenal, and for N^ε-(carboxymethyl)lysine (CML). Our findings demonstrate immunolocalization of 4-hydroxynonenal and CML to Lewy bodies in PD and DLBD. These findings not only support prior studies indicating that lipid peroxidation is increased in patients with PD and DLBD but that oxidative damage may play a critical role in Lewy body formation.

Original language	English (US)
Pages (from-to)	25-28
Number of pages	4
Journal	Neuroscience Letters
Volume	319
Issue number	1
DOIs	https://doi.org/10.1016/S0304-3940(01)02514-9
State	Published - Feb 8 2002

Funding

This work was supported by the NIH (NS38648 and AG14249), United Mitochondrial Disease Foundation and the Alzheimer's Association.

Keywords

Diffuse Lewy body disease
Hydroxynonenal
Lewy body
Lipid peroxidation
N-(carboxymethyl)lysine
Oxidative stress
Parkinson disease

ASJC Scopus subject areas

General Neuroscience

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title = "Hydroxynonenal adducts indicate a role for lipid peroxidation in neocortical and brainstem Lewy bodies in humans",

abstract = "Multiple lines of evidence indicate that oxidative stress is a critical pathogenic factor in Parkinson disease (PD) and diffuse Lewy body disease (DLBD). Previously, we demonstrated increased levels of redox-active iron in Lewy bodies, and that Lewy bodies accumulate advanced glycation end-products. To further characterize the role of oxidative stress in diseases with Lewy body formation, we examined immunocytochemically eight cases of PD and five cases of DLBD for adducts of the lipid peroxidation adduct 4-hydroxy-2-nonenal, and for Nε-(carboxymethyl)lysine (CML). Our findings demonstrate immunolocalization of 4-hydroxynonenal and CML to Lewy bodies in PD and DLBD. These findings not only support prior studies indicating that lipid peroxidation is increased in patients with PD and DLBD but that oxidative damage may play a critical role in Lewy body formation.",

keywords = "Diffuse Lewy body disease, Hydroxynonenal, Lewy body, Lipid peroxidation, N-(carboxymethyl)lysine, Oxidative stress, Parkinson disease",

author = "Castellani, {Rudy J.} and George Perry and Siedlak, {Sandra L.} and Akihiko Nunomura and Shun Shimohama and Jing Zhang and Thomas Montine and Sayre, {Lawrence M.} and Smith, {Mark A.}",

note = "Funding Information: This work was supported by the NIH (NS38648 and AG14249), United Mitochondrial Disease Foundation and the Alzheimer's Association.",

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doi = "10.1016/S0304-3940(01)02514-9",

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AU - Castellani, Rudy J.

AU - Perry, George

AU - Siedlak, Sandra L.

AU - Nunomura, Akihiko

AU - Shimohama, Shun

AU - Zhang, Jing

AU - Montine, Thomas

AU - Sayre, Lawrence M.

AU - Smith, Mark A.

N1 - Funding Information: This work was supported by the NIH (NS38648 and AG14249), United Mitochondrial Disease Foundation and the Alzheimer's Association.

PY - 2002/2/8

Y1 - 2002/2/8

N2 - Multiple lines of evidence indicate that oxidative stress is a critical pathogenic factor in Parkinson disease (PD) and diffuse Lewy body disease (DLBD). Previously, we demonstrated increased levels of redox-active iron in Lewy bodies, and that Lewy bodies accumulate advanced glycation end-products. To further characterize the role of oxidative stress in diseases with Lewy body formation, we examined immunocytochemically eight cases of PD and five cases of DLBD for adducts of the lipid peroxidation adduct 4-hydroxy-2-nonenal, and for Nε-(carboxymethyl)lysine (CML). Our findings demonstrate immunolocalization of 4-hydroxynonenal and CML to Lewy bodies in PD and DLBD. These findings not only support prior studies indicating that lipid peroxidation is increased in patients with PD and DLBD but that oxidative damage may play a critical role in Lewy body formation.

AB - Multiple lines of evidence indicate that oxidative stress is a critical pathogenic factor in Parkinson disease (PD) and diffuse Lewy body disease (DLBD). Previously, we demonstrated increased levels of redox-active iron in Lewy bodies, and that Lewy bodies accumulate advanced glycation end-products. To further characterize the role of oxidative stress in diseases with Lewy body formation, we examined immunocytochemically eight cases of PD and five cases of DLBD for adducts of the lipid peroxidation adduct 4-hydroxy-2-nonenal, and for Nε-(carboxymethyl)lysine (CML). Our findings demonstrate immunolocalization of 4-hydroxynonenal and CML to Lewy bodies in PD and DLBD. These findings not only support prior studies indicating that lipid peroxidation is increased in patients with PD and DLBD but that oxidative damage may play a critical role in Lewy body formation.

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KW - Lipid peroxidation

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Hydroxynonenal adducts indicate a role for lipid peroxidation in neocortical and brainstem Lewy bodies in humans

Abstract

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Keywords

ASJC Scopus subject areas

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