Hydroxynonenal adducts indicate a role for lipid peroxidation in neocortical and brainstem Lewy bodies in humans

Rudy J. Castellani; George Perry; Sandra L. Siedlak; Akihiko Nunomura; Shun Shimohama; Jing Zhang; Thomas Montine; Lawrence M. Sayre; Mark A. Smith

doi:10.1016/S0304-3940(01)02514-9

Hydroxynonenal adducts indicate a role for lipid peroxidation in neocortical and brainstem Lewy bodies in humans

Rudy J. Castellani, George Perry^*, Sandra L. Siedlak, Akihiko Nunomura, Shun Shimohama, Jing Zhang, Thomas Montine, Lawrence M. Sayre, Mark A. Smith

^*Corresponding author for this work

Pathology

Research output: Contribution to journal › Article › peer-review

151 Scopus citations

Abstract

Multiple lines of evidence indicate that oxidative stress is a critical pathogenic factor in Parkinson disease (PD) and diffuse Lewy body disease (DLBD). Previously, we demonstrated increased levels of redox-active iron in Lewy bodies, and that Lewy bodies accumulate advanced glycation end-products. To further characterize the role of oxidative stress in diseases with Lewy body formation, we examined immunocytochemically eight cases of PD and five cases of DLBD for adducts of the lipid peroxidation adduct 4-hydroxy-2-nonenal, and for N^ε-(carboxymethyl)lysine (CML). Our findings demonstrate immunolocalization of 4-hydroxynonenal and CML to Lewy bodies in PD and DLBD. These findings not only support prior studies indicating that lipid peroxidation is increased in patients with PD and DLBD but that oxidative damage may play a critical role in Lewy body formation.

Original language	English (US)
Pages (from-to)	25-28
Number of pages	4
Journal	Neuroscience Letters
Volume	319
Issue number	1
DOIs	https://doi.org/10.1016/S0304-3940(01)02514-9
State	Published - Feb 8 2002

Keywords

Diffuse Lewy body disease
Hydroxynonenal
Lewy body
Lipid peroxidation
N-(carboxymethyl)lysine
Oxidative stress
Parkinson disease

ASJC Scopus subject areas

Neuroscience(all)

Access to Document

10.1016/S0304-3940(01)02514-9

Cite this

@article{ee4f1645519242e48311f9d23c255e9a,

title = "Hydroxynonenal adducts indicate a role for lipid peroxidation in neocortical and brainstem Lewy bodies in humans",

abstract = "Multiple lines of evidence indicate that oxidative stress is a critical pathogenic factor in Parkinson disease (PD) and diffuse Lewy body disease (DLBD). Previously, we demonstrated increased levels of redox-active iron in Lewy bodies, and that Lewy bodies accumulate advanced glycation end-products. To further characterize the role of oxidative stress in diseases with Lewy body formation, we examined immunocytochemically eight cases of PD and five cases of DLBD for adducts of the lipid peroxidation adduct 4-hydroxy-2-nonenal, and for Nε-(carboxymethyl)lysine (CML). Our findings demonstrate immunolocalization of 4-hydroxynonenal and CML to Lewy bodies in PD and DLBD. These findings not only support prior studies indicating that lipid peroxidation is increased in patients with PD and DLBD but that oxidative damage may play a critical role in Lewy body formation.",

keywords = "Diffuse Lewy body disease, Hydroxynonenal, Lewy body, Lipid peroxidation, N-(carboxymethyl)lysine, Oxidative stress, Parkinson disease",

author = "Castellani, {Rudy J.} and George Perry and Siedlak, {Sandra L.} and Akihiko Nunomura and Shun Shimohama and Jing Zhang and Thomas Montine and Sayre, {Lawrence M.} and Smith, {Mark A.}",

note = "Funding Information: This work was supported by the NIH (NS38648 and AG14249), United Mitochondrial Disease Foundation and the Alzheimer's Association.",

year = "2002",

month = feb,

day = "8",

doi = "10.1016/S0304-3940(01)02514-9",

language = "English (US)",

volume = "319",

pages = "25--28",

journal = "Neuroscience Letters",

issn = "0304-3940",

publisher = "Elsevier Ireland Ltd",

number = "1",

}

TY - JOUR

T1 - Hydroxynonenal adducts indicate a role for lipid peroxidation in neocortical and brainstem Lewy bodies in humans

AU - Castellani, Rudy J.

AU - Perry, George

AU - Siedlak, Sandra L.

AU - Nunomura, Akihiko

AU - Shimohama, Shun

AU - Zhang, Jing

AU - Montine, Thomas

AU - Sayre, Lawrence M.

AU - Smith, Mark A.

N1 - Funding Information: This work was supported by the NIH (NS38648 and AG14249), United Mitochondrial Disease Foundation and the Alzheimer's Association.

PY - 2002/2/8

Y1 - 2002/2/8

N2 - Multiple lines of evidence indicate that oxidative stress is a critical pathogenic factor in Parkinson disease (PD) and diffuse Lewy body disease (DLBD). Previously, we demonstrated increased levels of redox-active iron in Lewy bodies, and that Lewy bodies accumulate advanced glycation end-products. To further characterize the role of oxidative stress in diseases with Lewy body formation, we examined immunocytochemically eight cases of PD and five cases of DLBD for adducts of the lipid peroxidation adduct 4-hydroxy-2-nonenal, and for Nε-(carboxymethyl)lysine (CML). Our findings demonstrate immunolocalization of 4-hydroxynonenal and CML to Lewy bodies in PD and DLBD. These findings not only support prior studies indicating that lipid peroxidation is increased in patients with PD and DLBD but that oxidative damage may play a critical role in Lewy body formation.

AB - Multiple lines of evidence indicate that oxidative stress is a critical pathogenic factor in Parkinson disease (PD) and diffuse Lewy body disease (DLBD). Previously, we demonstrated increased levels of redox-active iron in Lewy bodies, and that Lewy bodies accumulate advanced glycation end-products. To further characterize the role of oxidative stress in diseases with Lewy body formation, we examined immunocytochemically eight cases of PD and five cases of DLBD for adducts of the lipid peroxidation adduct 4-hydroxy-2-nonenal, and for Nε-(carboxymethyl)lysine (CML). Our findings demonstrate immunolocalization of 4-hydroxynonenal and CML to Lewy bodies in PD and DLBD. These findings not only support prior studies indicating that lipid peroxidation is increased in patients with PD and DLBD but that oxidative damage may play a critical role in Lewy body formation.

KW - Diffuse Lewy body disease

KW - Hydroxynonenal

KW - Lewy body

KW - Lipid peroxidation

KW - N-(carboxymethyl)lysine

KW - Oxidative stress

KW - Parkinson disease

UR - http://www.scopus.com/inward/record.url?scp=0037039837&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037039837&partnerID=8YFLogxK

U2 - 10.1016/S0304-3940(01)02514-9

DO - 10.1016/S0304-3940(01)02514-9

M3 - Article

C2 - 11814645

AN - SCOPUS:0037039837

SN - 0304-3940

VL - 319

SP - 25

EP - 28

JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 1

ER -

Hydroxynonenal adducts indicate a role for lipid peroxidation in neocortical and brainstem Lewy bodies in humans

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this