Hydroxynonenal adducts indicate a role for lipid peroxidation in neocortical and brainstem Lewy bodies in humans

Rudy J. Castellani, George Perry*, Sandra L. Siedlak, Akihiko Nunomura, Shun Shimohama, Jing Zhang, Thomas Montine, Lawrence M. Sayre, Mark A. Smith

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

159 Scopus citations

Abstract

Multiple lines of evidence indicate that oxidative stress is a critical pathogenic factor in Parkinson disease (PD) and diffuse Lewy body disease (DLBD). Previously, we demonstrated increased levels of redox-active iron in Lewy bodies, and that Lewy bodies accumulate advanced glycation end-products. To further characterize the role of oxidative stress in diseases with Lewy body formation, we examined immunocytochemically eight cases of PD and five cases of DLBD for adducts of the lipid peroxidation adduct 4-hydroxy-2-nonenal, and for Nε-(carboxymethyl)lysine (CML). Our findings demonstrate immunolocalization of 4-hydroxynonenal and CML to Lewy bodies in PD and DLBD. These findings not only support prior studies indicating that lipid peroxidation is increased in patients with PD and DLBD but that oxidative damage may play a critical role in Lewy body formation.

Original languageEnglish (US)
Pages (from-to)25-28
Number of pages4
JournalNeuroscience Letters
Volume319
Issue number1
DOIs
StatePublished - Feb 8 2002

Keywords

  • Diffuse Lewy body disease
  • Hydroxynonenal
  • Lewy body
  • Lipid peroxidation
  • N-(carboxymethyl)lysine
  • Oxidative stress
  • Parkinson disease

ASJC Scopus subject areas

  • General Neuroscience

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