Hydroxyurea-associated squamous dysplasia.

Carla Sanchez-Palacios*, Joan Guitart

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

50 Scopus citations


We report 2 cases of squamous dysplasia associated with long-term hydroxyurea therapy. The association between hydroxyurea and multiple aggressive squamous cell carcinomas, Bowen's disease, and multiple actinic keratoses in sun-exposed areas after a variable latency period has been increasingly reported. On reviewing the literature, 17 cases were identified and are reviewed, with emphasis on possible pathogenetic mechanisms of carcinogenicity. Squamous dysplasia, a precursor state to a more aggressive condition of multiple squamous cell carcinomas in photoexposed areas, should be added to the well-known cutaneous toxicities of hydroxyurea therapy.

Original languageEnglish (US)
Pages (from-to)293-300
Number of pages8
JournalJournal of the American Academy of Dermatology
Issue number2
StatePublished - Aug 2004

ASJC Scopus subject areas

  • Dermatology


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