TY - JOUR
T1 - Hydroxyurea therapy for priapism prevention and erectile function recovery in sickle cell disease
T2 - a case report and review of the literature
AU - Anele, Uzoma A.
AU - Mack, A. Kyle
AU - Resar, Linda M.S.
AU - Burnett, Arthur L.
PY - 2014/9/1
Y1 - 2014/9/1
N2 - Prolonged ischemic priapism in patients with sickling hemoglobinopathies is a urologic emergency requiring immediate intervention to avoid irreversible anoxic penile injury, corporal fibrosis, and erectile dysfunction. Therapeutic options, however, are limited and often ineffective. Here, we report recovery of erectile function with hydroxyurea therapy in an adolescent with hemoglobin SS following a prolonged episode of priapism and subsequent severe erectile dysfunction. This case suggests a potential role of hydroxyurea in reversing end organ damage in patients with hemoglobin SS and also supports basic science work indicating involvement of the NO-dependent pathway in the pathogenesis of sickle cell disease-associated priapism.
AB - Prolonged ischemic priapism in patients with sickling hemoglobinopathies is a urologic emergency requiring immediate intervention to avoid irreversible anoxic penile injury, corporal fibrosis, and erectile dysfunction. Therapeutic options, however, are limited and often ineffective. Here, we report recovery of erectile function with hydroxyurea therapy in an adolescent with hemoglobin SS following a prolonged episode of priapism and subsequent severe erectile dysfunction. This case suggests a potential role of hydroxyurea in reversing end organ damage in patients with hemoglobin SS and also supports basic science work indicating involvement of the NO-dependent pathway in the pathogenesis of sickle cell disease-associated priapism.
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U2 - 10.1007/s11255-014-0737-7
DO - 10.1007/s11255-014-0737-7
M3 - Article
C2 - 24824148
AN - SCOPUS:85027944233
VL - 46
SP - 1733
EP - 1736
JO - International Urology and Nephrology
JF - International Urology and Nephrology
SN - 0301-1623
IS - 9
ER -