TY - JOUR
T1 - Hypercalcemia and Increases in Serum Hormone Value during Prolonged Administration of 1α,25-Dihydroxyvitamin D
AU - Bell, N. H.
AU - Stern, P. H.
PY - 1978/6/1
Y1 - 1978/6/1
N2 - PREVIOUS studies have indicated that in pseudohypoparathyroidism there is a defect in the renal production of 1α,25-dihydroxyvitamin D. The mean concentration of the hormone in the circulation is abnormally low.12 We have reported in short-term studies that impaired intestinal absorption of calcium, hypocalcemia and secondary hyperparathyroidism can be corrected by small doses of 14α,25-dihydroxyvitamin D3.13 We now describe some complications of the long-term use of 1α,25-dihydroxyvitamin D3 in pseudohypoparathyroidism. We find that increases in serum 1α,25-dihydroxyvitamin D3 may occur after its prolonged administration, and that these increases in hormone value are associated with hypercalcemia. The increased.
AB - PREVIOUS studies have indicated that in pseudohypoparathyroidism there is a defect in the renal production of 1α,25-dihydroxyvitamin D. The mean concentration of the hormone in the circulation is abnormally low.12 We have reported in short-term studies that impaired intestinal absorption of calcium, hypocalcemia and secondary hyperparathyroidism can be corrected by small doses of 14α,25-dihydroxyvitamin D3.13 We now describe some complications of the long-term use of 1α,25-dihydroxyvitamin D3 in pseudohypoparathyroidism. We find that increases in serum 1α,25-dihydroxyvitamin D3 may occur after its prolonged administration, and that these increases in hormone value are associated with hypercalcemia. The increased.
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U2 - 10.1056/NEJM197806012982206
DO - 10.1056/NEJM197806012982206
M3 - Article
C2 - 651964
AN - SCOPUS:0018192650
SN - 0028-4793
VL - 298
SP - 1241
EP - 1243
JO - New England Journal of Medicine
JF - New England Journal of Medicine
IS - 22
ER -