Hypercalcemia and Increases in Serum Hormone Value during Prolonged Administration of 1α,25-Dihydroxyvitamin D

N. H. Bell, P. H. Stern

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27 Scopus citations

Abstract

PREVIOUS studies have indicated that in pseudohypoparathyroidism there is a defect in the renal production of 1α,25-dihydroxyvitamin D. The mean concentration of the hormone in the circulation is abnormally low.12 We have reported in short-term studies that impaired intestinal absorption of calcium, hypocalcemia and secondary hyperparathyroidism can be corrected by small doses of 14α,25-dihydroxyvitamin D3.13 We now describe some complications of the long-term use of 1α,25-dihydroxyvitamin D3 in pseudohypoparathyroidism. We find that increases in serum 1α,25-dihydroxyvitamin D3 may occur after its prolonged administration, and that these increases in hormone value are associated with hypercalcemia. The increased.

Original languageEnglish (US)
Pages (from-to)1241-1243
Number of pages3
JournalNew England Journal of Medicine
Volume298
Issue number22
DOIs
StatePublished - Jun 1 1978

ASJC Scopus subject areas

  • Medicine(all)

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