TY - JOUR
T1 - Hypercatabolic Syndrome
T2 - Molecular Basis and Effects of Nutritional Supplements with Amino Acids
AU - Pasini, Evasio
AU - Aquilani, Roberto
AU - Dioguardi, Francesco S.
AU - D'Antona, Giuseppe
AU - Gheorghiade, Mihai
AU - Taegtmeyer, Heinrich
PY - 2008/6/2
Y1 - 2008/6/2
N2 - Hypercatabolic syndrome (HS) is a biochemical state characterized by increased circulating catabolic hormones (eg, cortisol, catecholamines) and inflammatory cytokines (eg, tumor necrosis factors, interleukin-1β), and decreased anabolic insulin effects with consequent insulin resistance. The most important metabolic consequence of HS is the skeletal and cardiac muscle protein breakdown that releases amino acids (AAs), which in turn supports indispensable body energy requirements but also reduces skeletal and cardiac physiologic and metabolic functions. HS occurs in many diseases such as diabetes mellitus, chronic heart failure, chronic obstructive pulmonary disease, renal and liver failure, trauma, sepsis, and senescence. All of these conditions have predominant catabolic molecules with significant muscular wasting and metabolic impairment. Macronutrients such as AA supplements, taken together with conventional therapy, may maintain muscular protein metabolism and cell functions.
AB - Hypercatabolic syndrome (HS) is a biochemical state characterized by increased circulating catabolic hormones (eg, cortisol, catecholamines) and inflammatory cytokines (eg, tumor necrosis factors, interleukin-1β), and decreased anabolic insulin effects with consequent insulin resistance. The most important metabolic consequence of HS is the skeletal and cardiac muscle protein breakdown that releases amino acids (AAs), which in turn supports indispensable body energy requirements but also reduces skeletal and cardiac physiologic and metabolic functions. HS occurs in many diseases such as diabetes mellitus, chronic heart failure, chronic obstructive pulmonary disease, renal and liver failure, trauma, sepsis, and senescence. All of these conditions have predominant catabolic molecules with significant muscular wasting and metabolic impairment. Macronutrients such as AA supplements, taken together with conventional therapy, may maintain muscular protein metabolism and cell functions.
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U2 - 10.1016/j.amjcard.2008.02.074
DO - 10.1016/j.amjcard.2008.02.074
M3 - Article
C2 - 18514619
AN - SCOPUS:44449095465
VL - 101
SP - S11-S15
JO - American Journal of Cardiology
JF - American Journal of Cardiology
SN - 0002-9149
IS - 11 SUPPL.
ER -