Hypercortisolism and Depression

M. T. Lowy, A. T. Reder, H. Y. Meltzer

Research output: Contribution to journalLetterpeer-review

5 Scopus citations


To the Editor: Holsboer and associates report on the use of human corticotropin-releasing factor to investigate the basis for the hypercortisolism frequently observed in depression (Oct. 25 issue).1 As previously discussed, the availability of corticotropin-releasing factor offers a new approach for the study of the pathophysiology of various disorders of the hypothalamic–pituitary–adrenal axis.2 However, we believe it is premature for Holsboer et al. to suggest that the basis for the elevated serum cortisol levels in depressed patients is due to a suprapituitary defect. They report that after administration of human corticotropin-releasing factor (100 μg, intravenously), depressed patients had a blunted.

Original languageEnglish (US)
Pages (from-to)791-792
Number of pages2
JournalNew England Journal of Medicine
Issue number12
StatePublished - Mar 21 1985

ASJC Scopus subject areas

  • Medicine(all)


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