Hyperglycemia and adverse Pregnancy Outcome follow-up study (HAPO FUS)

Maternal glycemia and childhood glucose metabolism

the HAPO Follow-up Study Cooperative Research Group

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

OBJECTIVE This study examined associations of maternal glycemia during pregnancy with childhood glucose outcomes in the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) cohort. RESEARCH DESIGN AND METHODS HAPO was an observational international investigation that established associations of maternal glucose with adverse perinatal outcomes. The HAPO Follow-up Study included 4,832 children ages 10–14 years whose mothers had a 75-g oral glucose tolerance test (OGTT) at ∼28 weeks of gestation. Of these, 4,160 children were evaluated for glucose outcomes. Primary outcomes were child impaired glucose tolerance (IGT) and impaired fasting glucose (IFG). Additional outcomes were glucose-related measures using plasma glucose (PG), A1C, and C-peptide from the child OGTT. RESULTS Maternal fasting plasma glucose (FPG) was positively associated with child FPG and A1C; maternal 1-h and 2-h PG were positively associated with child fasting, 30 min, 1-h, and 2-h PG, and A1C. Maternal FPG, 1-h, and 2-h PG were inversely associated with insulin sensitivity, whereas 1-h and 2-h PG were inversely associated with disposition index. Maternal FPG, but not 1-h or 2-h PG, was associated with child IFG, and maternal 1-h and 2-h PG, but not FPG, were associated with child IGT. All associations were independent of maternal and child BMI. Across increasing categories of maternal glucose, frequencies of child IFG and IGT, and timed PG measures and A1C were higher, whereas insulin sensitivity and disposition index decreased. CONCLUSIONS Across the maternal glucose spectrum, exposure to higher levels in utero is significantly associated with childhood glucose and insulin resistance independent of maternal and childhood BMI and family history of diabetes.

Original languageEnglish (US)
Pages (from-to)381-392
Number of pages12
JournalDiabetes care
Volume42
Issue number3
DOIs
StatePublished - Mar 1 2019

Fingerprint

Pregnancy Outcome
Hyperglycemia
Mothers
Glucose
Fasting
Glucose Intolerance
Insulin Resistance
Glucose Tolerance Test
Pregnancy

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialized Nursing

Cite this

the HAPO Follow-up Study Cooperative Research Group. / Hyperglycemia and adverse Pregnancy Outcome follow-up study (HAPO FUS) : Maternal glycemia and childhood glucose metabolism. In: Diabetes care. 2019 ; Vol. 42, No. 3. pp. 381-392.
@article{8e52e2a6c74042b9967af0db1ffa02e6,
title = "Hyperglycemia and adverse Pregnancy Outcome follow-up study (HAPO FUS): Maternal glycemia and childhood glucose metabolism",
abstract = "OBJECTIVE This study examined associations of maternal glycemia during pregnancy with childhood glucose outcomes in the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) cohort. RESEARCH DESIGN AND METHODS HAPO was an observational international investigation that established associations of maternal glucose with adverse perinatal outcomes. The HAPO Follow-up Study included 4,832 children ages 10–14 years whose mothers had a 75-g oral glucose tolerance test (OGTT) at ∼28 weeks of gestation. Of these, 4,160 children were evaluated for glucose outcomes. Primary outcomes were child impaired glucose tolerance (IGT) and impaired fasting glucose (IFG). Additional outcomes were glucose-related measures using plasma glucose (PG), A1C, and C-peptide from the child OGTT. RESULTS Maternal fasting plasma glucose (FPG) was positively associated with child FPG and A1C; maternal 1-h and 2-h PG were positively associated with child fasting, 30 min, 1-h, and 2-h PG, and A1C. Maternal FPG, 1-h, and 2-h PG were inversely associated with insulin sensitivity, whereas 1-h and 2-h PG were inversely associated with disposition index. Maternal FPG, but not 1-h or 2-h PG, was associated with child IFG, and maternal 1-h and 2-h PG, but not FPG, were associated with child IGT. All associations were independent of maternal and child BMI. Across increasing categories of maternal glucose, frequencies of child IFG and IGT, and timed PG measures and A1C were higher, whereas insulin sensitivity and disposition index decreased. CONCLUSIONS Across the maternal glucose spectrum, exposure to higher levels in utero is significantly associated with childhood glucose and insulin resistance independent of maternal and childhood BMI and family history of diabetes.",
author = "{the HAPO Follow-up Study Cooperative Research Group} and Scholtens, {Denise M} and Alan Kuang and Lowe, {Lynn Peterson} and Jill Hamilton and Lawrence, {Jean M.} and Yael Lebenthal and Brickman, {Wendy Joy} and Peter Clayton and Ma, {Ronald C.} and David McCance and Tam, {Wing Hung} and Catalano, {Patrick M.} and Barbara Linder and Dyer, {Alan Richard} and {Lowe Jr}, {William L} and Metzger, {Boyd E}",
year = "2019",
month = "3",
day = "1",
doi = "10.2337/dc18-2021",
language = "English (US)",
volume = "42",
pages = "381--392",
journal = "Diabetes Care",
issn = "1935-5548",
publisher = "American Diabetes Association Inc.",
number = "3",

}

Hyperglycemia and adverse Pregnancy Outcome follow-up study (HAPO FUS) : Maternal glycemia and childhood glucose metabolism. / the HAPO Follow-up Study Cooperative Research Group.

In: Diabetes care, Vol. 42, No. 3, 01.03.2019, p. 381-392.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Hyperglycemia and adverse Pregnancy Outcome follow-up study (HAPO FUS)

T2 - Maternal glycemia and childhood glucose metabolism

AU - the HAPO Follow-up Study Cooperative Research Group

AU - Scholtens, Denise M

AU - Kuang, Alan

AU - Lowe, Lynn Peterson

AU - Hamilton, Jill

AU - Lawrence, Jean M.

AU - Lebenthal, Yael

AU - Brickman, Wendy Joy

AU - Clayton, Peter

AU - Ma, Ronald C.

AU - McCance, David

AU - Tam, Wing Hung

AU - Catalano, Patrick M.

AU - Linder, Barbara

AU - Dyer, Alan Richard

AU - Lowe Jr, William L

AU - Metzger, Boyd E

PY - 2019/3/1

Y1 - 2019/3/1

N2 - OBJECTIVE This study examined associations of maternal glycemia during pregnancy with childhood glucose outcomes in the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) cohort. RESEARCH DESIGN AND METHODS HAPO was an observational international investigation that established associations of maternal glucose with adverse perinatal outcomes. The HAPO Follow-up Study included 4,832 children ages 10–14 years whose mothers had a 75-g oral glucose tolerance test (OGTT) at ∼28 weeks of gestation. Of these, 4,160 children were evaluated for glucose outcomes. Primary outcomes were child impaired glucose tolerance (IGT) and impaired fasting glucose (IFG). Additional outcomes were glucose-related measures using plasma glucose (PG), A1C, and C-peptide from the child OGTT. RESULTS Maternal fasting plasma glucose (FPG) was positively associated with child FPG and A1C; maternal 1-h and 2-h PG were positively associated with child fasting, 30 min, 1-h, and 2-h PG, and A1C. Maternal FPG, 1-h, and 2-h PG were inversely associated with insulin sensitivity, whereas 1-h and 2-h PG were inversely associated with disposition index. Maternal FPG, but not 1-h or 2-h PG, was associated with child IFG, and maternal 1-h and 2-h PG, but not FPG, were associated with child IGT. All associations were independent of maternal and child BMI. Across increasing categories of maternal glucose, frequencies of child IFG and IGT, and timed PG measures and A1C were higher, whereas insulin sensitivity and disposition index decreased. CONCLUSIONS Across the maternal glucose spectrum, exposure to higher levels in utero is significantly associated with childhood glucose and insulin resistance independent of maternal and childhood BMI and family history of diabetes.

AB - OBJECTIVE This study examined associations of maternal glycemia during pregnancy with childhood glucose outcomes in the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) cohort. RESEARCH DESIGN AND METHODS HAPO was an observational international investigation that established associations of maternal glucose with adverse perinatal outcomes. The HAPO Follow-up Study included 4,832 children ages 10–14 years whose mothers had a 75-g oral glucose tolerance test (OGTT) at ∼28 weeks of gestation. Of these, 4,160 children were evaluated for glucose outcomes. Primary outcomes were child impaired glucose tolerance (IGT) and impaired fasting glucose (IFG). Additional outcomes were glucose-related measures using plasma glucose (PG), A1C, and C-peptide from the child OGTT. RESULTS Maternal fasting plasma glucose (FPG) was positively associated with child FPG and A1C; maternal 1-h and 2-h PG were positively associated with child fasting, 30 min, 1-h, and 2-h PG, and A1C. Maternal FPG, 1-h, and 2-h PG were inversely associated with insulin sensitivity, whereas 1-h and 2-h PG were inversely associated with disposition index. Maternal FPG, but not 1-h or 2-h PG, was associated with child IFG, and maternal 1-h and 2-h PG, but not FPG, were associated with child IGT. All associations were independent of maternal and child BMI. Across increasing categories of maternal glucose, frequencies of child IFG and IGT, and timed PG measures and A1C were higher, whereas insulin sensitivity and disposition index decreased. CONCLUSIONS Across the maternal glucose spectrum, exposure to higher levels in utero is significantly associated with childhood glucose and insulin resistance independent of maternal and childhood BMI and family history of diabetes.

UR - http://www.scopus.com/inward/record.url?scp=85061941599&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85061941599&partnerID=8YFLogxK

U2 - 10.2337/dc18-2021

DO - 10.2337/dc18-2021

M3 - Article

VL - 42

SP - 381

EP - 392

JO - Diabetes Care

JF - Diabetes Care

SN - 1935-5548

IS - 3

ER -