Abstract
This report describes the occurrence of hyperkalemic hyperchloremic metabolic acidosis in six patients with sickle cell hemoglobinopathies. Three patients had sickle cell anemia, two had sickle cell trait and one had S-C disease. In all patients, decreased renal potassium excretion was demonstrated by the finding of a fractional potassium excretion lower than that of control subjects with comparable glomerular filtration rates. Two patterns of impaired urinary acidification were discerned. Four patients had a urinary pH above 5.5 in the presence of systemic acidosis and, thus, were classified as having distal renal tubular acidosis. The remaining two patients had very low rates of ammonium excretion despite intact capacity to lower urinary pH below 5.5 during systemic acidosis; this pattern was ascribed to selective aldosterone deficiency. Sickle cell hemoglobinopathies should be included in the differential diagnosis of hyperkalemic hyperchloremic metabolic acidosis.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 188-192 |
| Number of pages | 5 |
| Journal | The American journal of medicine |
| Volume | 72 |
| Issue number | 2 |
| DOIs | |
| State | Published - Feb 1982 |
Funding
From the Section of Nephroiogy, University of II-linois Abraham Lincoln School of Medicine, and the Veterans Administration West Side Hospital. Chicago, Illinois. This work was supported in part by the National institutes of Health. grant #AM20170. Parts of this work were presented at the 13tf1 Annual Meeting of the American Society of Nephrokgy. Washington, D.C., November 1980. Repint requests shouid be addressed to Dr. Daniel E&tile, Section of Nephroiogy, University of Illinois Hospital, 840 South Wood Street. Chicago, Illinois 60612. Manuscript accepted September 28. 1981.
ASJC Scopus subject areas
- General Medicine