Hypertension-induced cognitive impairment: from pathophysiology to public health

Zoltan Ungvari, Peter Toth, Stefano Tarantini, Calin I. Prodan, Farzaneh Sorond, Bela Merkely, Anna Csiszar*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

167 Scopus citations


Hypertension affects two-thirds of people aged >60 years and significantly increases the risk of both vascular cognitive impairment and Alzheimer’s disease. Hypertension compromises the structural and functional integrity of the cerebral microcirculation, promoting microvascular rarefaction, cerebromicrovascular endothelial dysfunction and neurovascular uncoupling, which impair cerebral blood supply. In addition, hypertension disrupts the blood–brain barrier, promoting neuroinflammation and exacerbation of amyloid pathologies. Ageing is characterized by multifaceted homeostatic dysfunction and impaired cellular stress resilience, which exacerbate the deleterious cerebromicrovascular effects of hypertension. Neuroradiological markers of hypertension-induced cerebral small vessel disease include white matter hyperintensities, lacunar infarcts and microhaemorrhages, all of which are associated with cognitive decline. Use of pharmaceutical and lifestyle interventions that reduce blood pressure, in combination with treatments that promote microvascular health, have the potential to prevent or delay the pathogenesis of vascular cognitive impairment and Alzheimer’s disease in patients with hypertension.

Original languageEnglish (US)
Pages (from-to)639-654
Number of pages16
JournalNature Reviews Nephrology
Issue number10
StatePublished - Oct 2021

ASJC Scopus subject areas

  • Nephrology


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