Hypertensive heart disease: MR tissue phase mapping reveals altered left ventricular rotation and regional myocardial long-axis velocities

D. Foell*, B. Jung, E. Germann, F. Staehle, C. Bode, M. Markl

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Objectives: The aim of this study was the evaluation of left ventricular (LV) segmental 3D velocities in patients with hypertensive heart disease using magnetic resonance (MR) tissue phase mapping (TPM). Methods: LV radial, long-axis and rotational myocardial velocities were assessed by TPM in patients with LV hypertrophy and preserved EF (n = 18, age = 53 ± 12 years) and volunteers (n = 20, age = 51 ± 4 years). Systolic and diastolic peak and time-to-peak velocities were mapped onto a 16-segment LV model. 3D myocardial motion was displayed on an extended visualisation model. Correlation coefficients were calculated to investigate differences in regional dynamics. Results: Patients revealed diastolic dysfunction as expressed by decreased peak long-axis velocities in all (except apical) segments (basal, P ≤ 0.01; two midventricular segments, P = 0.02, P = 0.03). During systole, hypertrophy was associated with heterogeneous behaviour for long-axis velocities including an increase in anteroseptal apical and midventricular regions (P = 0.001), a reduction in mid-inferior segments (P = 0.03) and enhanced septal velocities (P < 0.05). Segmental correlation analysis revealed altered dynamics of LV base rotation and increased dyssynchrony of lateral long-axis motion. Conclusions: Patients with hypertensive heart disease demonstrated alterations in systolic long-axis motion, basal rotation and dyssynchrony. Longitudinal studies are needed to investigate the value of regional wall motion abnormalities regarding disease progression and outcome. Key Points: • Magnetic resonance tissue phase mapping enables segmental evaluation of 3D myocardial velocities. • Patients with hypertensive heart disease demonstrated new alterations in systolic long-axis motion. • Correlation analysis revealed left ventricular long-axis dyssynchrony and an altered rotation. • MR may provide new, sensitive diagnostic markers concerning hypertensive heart disease.

Original languageEnglish (US)
Pages (from-to)339-347
Number of pages9
JournalEuropean Radiology
Volume23
Issue number2
DOIs
StatePublished - Jan 1 2013

Keywords

  • Diastole
  • Hypertension
  • MRI
  • Myocardium
  • Ventricular function

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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