Hypertensive heart disease: MR tissue phase mapping reveals altered left ventricular rotation and regional myocardial long-axis velocities

D. Foell; B. Jung; E. Germann; F. Staehle; C. Bode; M. Markl

doi:10.1007/s00330-012-2613-0

Hypertensive heart disease: MR tissue phase mapping reveals altered left ventricular rotation and regional myocardial long-axis velocities

D. Foell^*, B. Jung, E. Germann, F. Staehle, C. Bode, M. Markl

^*Corresponding author for this work

Radiology

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

Objectives: The aim of this study was the evaluation of left ventricular (LV) segmental 3D velocities in patients with hypertensive heart disease using magnetic resonance (MR) tissue phase mapping (TPM). Methods: LV radial, long-axis and rotational myocardial velocities were assessed by TPM in patients with LV hypertrophy and preserved EF (n = 18, age = 53 ± 12 years) and volunteers (n = 20, age = 51 ± 4 years). Systolic and diastolic peak and time-to-peak velocities were mapped onto a 16-segment LV model. 3D myocardial motion was displayed on an extended visualisation model. Correlation coefficients were calculated to investigate differences in regional dynamics. Results: Patients revealed diastolic dysfunction as expressed by decreased peak long-axis velocities in all (except apical) segments (basal, P ≤ 0.01; two midventricular segments, P = 0.02, P = 0.03). During systole, hypertrophy was associated with heterogeneous behaviour for long-axis velocities including an increase in anteroseptal apical and midventricular regions (P = 0.001), a reduction in mid-inferior segments (P = 0.03) and enhanced septal velocities (P < 0.05). Segmental correlation analysis revealed altered dynamics of LV base rotation and increased dyssynchrony of lateral long-axis motion. Conclusions: Patients with hypertensive heart disease demonstrated alterations in systolic long-axis motion, basal rotation and dyssynchrony. Longitudinal studies are needed to investigate the value of regional wall motion abnormalities regarding disease progression and outcome. Key Points: • Magnetic resonance tissue phase mapping enables segmental evaluation of 3D myocardial velocities. • Patients with hypertensive heart disease demonstrated new alterations in systolic long-axis motion. • Correlation analysis revealed left ventricular long-axis dyssynchrony and an altered rotation. • MR may provide new, sensitive diagnostic markers concerning hypertensive heart disease.

Original language	English (US)
Pages (from-to)	339-347
Number of pages	9
Journal	European Radiology
Volume	23
Issue number	2
DOIs	https://doi.org/10.1007/s00330-012-2613-0
State	Published - Feb 2013

Funding

Michael Markl is supported by the NMH Excellence in Academic Medicine (EAM) Program ‘Advanced Cardiovascular MRI Research Center'. Daniela Föll is supported by the Deutsche Forschungsgemeinschaft (DFG; grant no. FO 507/2-1, FO 507/3-1)

Keywords

Diastole
Hypertension
MRI
Myocardium
Ventricular function

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

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10.1007/s00330-012-2613-0

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@article{4eec5cdcce734d91acd97a449492a9c2,

title = "Hypertensive heart disease: MR tissue phase mapping reveals altered left ventricular rotation and regional myocardial long-axis velocities",

abstract = "Objectives: The aim of this study was the evaluation of left ventricular (LV) segmental 3D velocities in patients with hypertensive heart disease using magnetic resonance (MR) tissue phase mapping (TPM). Methods: LV radial, long-axis and rotational myocardial velocities were assessed by TPM in patients with LV hypertrophy and preserved EF (n = 18, age = 53 ± 12 years) and volunteers (n = 20, age = 51 ± 4 years). Systolic and diastolic peak and time-to-peak velocities were mapped onto a 16-segment LV model. 3D myocardial motion was displayed on an extended visualisation model. Correlation coefficients were calculated to investigate differences in regional dynamics. Results: Patients revealed diastolic dysfunction as expressed by decreased peak long-axis velocities in all (except apical) segments (basal, P ≤ 0.01; two midventricular segments, P = 0.02, P = 0.03). During systole, hypertrophy was associated with heterogeneous behaviour for long-axis velocities including an increase in anteroseptal apical and midventricular regions (P = 0.001), a reduction in mid-inferior segments (P = 0.03) and enhanced septal velocities (P < 0.05). Segmental correlation analysis revealed altered dynamics of LV base rotation and increased dyssynchrony of lateral long-axis motion. Conclusions: Patients with hypertensive heart disease demonstrated alterations in systolic long-axis motion, basal rotation and dyssynchrony. Longitudinal studies are needed to investigate the value of regional wall motion abnormalities regarding disease progression and outcome. Key Points: • Magnetic resonance tissue phase mapping enables segmental evaluation of 3D myocardial velocities. • Patients with hypertensive heart disease demonstrated new alterations in systolic long-axis motion. • Correlation analysis revealed left ventricular long-axis dyssynchrony and an altered rotation. • MR may provide new, sensitive diagnostic markers concerning hypertensive heart disease.",

keywords = "Diastole, Hypertension, MRI, Myocardium, Ventricular function",

author = "D. Foell and B. Jung and E. Germann and F. Staehle and C. Bode and M. Markl",

note = "Funding Information: Michael Markl is supported by the NMH Excellence in Academic Medicine (EAM) Program {\textquoteleft}Advanced Cardiovascular MRI Research Center'. Daniela F{\"o}ll is supported by the Deutsche Forschungsgemeinschaft (DFG; grant no. FO 507/2-1, FO 507/3-1) ",

year = "2013",

month = feb,

doi = "10.1007/s00330-012-2613-0",

language = "English (US)",

volume = "23",

pages = "339--347",

journal = "European Radiology",

issn = "0938-7994",

publisher = "Springer Verlag",

number = "2",

}

TY - JOUR

T1 - Hypertensive heart disease

T2 - MR tissue phase mapping reveals altered left ventricular rotation and regional myocardial long-axis velocities

AU - Foell, D.

AU - Jung, B.

AU - Germann, E.

AU - Staehle, F.

AU - Bode, C.

AU - Markl, M.

N1 - Funding Information: Michael Markl is supported by the NMH Excellence in Academic Medicine (EAM) Program ‘Advanced Cardiovascular MRI Research Center'. Daniela Föll is supported by the Deutsche Forschungsgemeinschaft (DFG; grant no. FO 507/2-1, FO 507/3-1)

PY - 2013/2

Y1 - 2013/2

N2 - Objectives: The aim of this study was the evaluation of left ventricular (LV) segmental 3D velocities in patients with hypertensive heart disease using magnetic resonance (MR) tissue phase mapping (TPM). Methods: LV radial, long-axis and rotational myocardial velocities were assessed by TPM in patients with LV hypertrophy and preserved EF (n = 18, age = 53 ± 12 years) and volunteers (n = 20, age = 51 ± 4 years). Systolic and diastolic peak and time-to-peak velocities were mapped onto a 16-segment LV model. 3D myocardial motion was displayed on an extended visualisation model. Correlation coefficients were calculated to investigate differences in regional dynamics. Results: Patients revealed diastolic dysfunction as expressed by decreased peak long-axis velocities in all (except apical) segments (basal, P ≤ 0.01; two midventricular segments, P = 0.02, P = 0.03). During systole, hypertrophy was associated with heterogeneous behaviour for long-axis velocities including an increase in anteroseptal apical and midventricular regions (P = 0.001), a reduction in mid-inferior segments (P = 0.03) and enhanced septal velocities (P < 0.05). Segmental correlation analysis revealed altered dynamics of LV base rotation and increased dyssynchrony of lateral long-axis motion. Conclusions: Patients with hypertensive heart disease demonstrated alterations in systolic long-axis motion, basal rotation and dyssynchrony. Longitudinal studies are needed to investigate the value of regional wall motion abnormalities regarding disease progression and outcome. Key Points: • Magnetic resonance tissue phase mapping enables segmental evaluation of 3D myocardial velocities. • Patients with hypertensive heart disease demonstrated new alterations in systolic long-axis motion. • Correlation analysis revealed left ventricular long-axis dyssynchrony and an altered rotation. • MR may provide new, sensitive diagnostic markers concerning hypertensive heart disease.

AB - Objectives: The aim of this study was the evaluation of left ventricular (LV) segmental 3D velocities in patients with hypertensive heart disease using magnetic resonance (MR) tissue phase mapping (TPM). Methods: LV radial, long-axis and rotational myocardial velocities were assessed by TPM in patients with LV hypertrophy and preserved EF (n = 18, age = 53 ± 12 years) and volunteers (n = 20, age = 51 ± 4 years). Systolic and diastolic peak and time-to-peak velocities were mapped onto a 16-segment LV model. 3D myocardial motion was displayed on an extended visualisation model. Correlation coefficients were calculated to investigate differences in regional dynamics. Results: Patients revealed diastolic dysfunction as expressed by decreased peak long-axis velocities in all (except apical) segments (basal, P ≤ 0.01; two midventricular segments, P = 0.02, P = 0.03). During systole, hypertrophy was associated with heterogeneous behaviour for long-axis velocities including an increase in anteroseptal apical and midventricular regions (P = 0.001), a reduction in mid-inferior segments (P = 0.03) and enhanced septal velocities (P < 0.05). Segmental correlation analysis revealed altered dynamics of LV base rotation and increased dyssynchrony of lateral long-axis motion. Conclusions: Patients with hypertensive heart disease demonstrated alterations in systolic long-axis motion, basal rotation and dyssynchrony. Longitudinal studies are needed to investigate the value of regional wall motion abnormalities regarding disease progression and outcome. Key Points: • Magnetic resonance tissue phase mapping enables segmental evaluation of 3D myocardial velocities. • Patients with hypertensive heart disease demonstrated new alterations in systolic long-axis motion. • Correlation analysis revealed left ventricular long-axis dyssynchrony and an altered rotation. • MR may provide new, sensitive diagnostic markers concerning hypertensive heart disease.

KW - Diastole

KW - Hypertension

KW - MRI

KW - Myocardium

KW - Ventricular function

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Hypertensive heart disease: MR tissue phase mapping reveals altered left ventricular rotation and regional myocardial long-axis velocities

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