Hyperthermia and radiation in the treatment of superficial malignancy: An analysis of treatment parameters, response and toxicity

G. C W Howard, V. Sathiaseelan, L. Freedman, N. M. Bleehen

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

A total of 41 superficial tumours have been treated with radiation alone (21 lesions) or in combination with hyperthermia (20 lesions) in a non-randomized study on 16 patients. A minimum tumour heat dose in excess of 30 min equivalent at 43°C was achieved in 46 of the 80 (57 per cent) hyperthermia treatments. Small lesions received better quality heat treatments and were more likely to achieve a complete response. There is a significant increase in the response of lesions treated with the combined modality compared with radiation alone (P > 0.01). Similar results were obtained when matched lesions with internal controls were analysed separately. There was an increased incidence of severe skin reactions in the hyperthermia-treated group with the reaction tending to develop more quickly. There were three instances of late fibrosis in the hyperthermia group. There is a significant correlation between the severity of the skin reaction and the average maximum skin heat dose per treatment.

Original languageEnglish (US)
Pages (from-to)1-8
Number of pages8
JournalInternational Journal of Hyperthermia
Volume3
Issue number1
DOIs
StatePublished - Jan 1 1987

Keywords

  • Hyperthermia
  • Thermal enhancement
  • Thermal toxicity

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)
  • Cancer Research

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