Hypertrophic Cardiomyopathy

B. J. Maron, R. O. Bonow, R. O. Cannon, M. B. Leon, S. E. Epstein

Research output: Contribution to journalReview articlepeer-review

381 Scopus citations


(Second of Two Parts) Interrelation between Pathophysiologic Mechanisms and Disease Manifestations Symptoms The chief symptoms of hypertrophic cardiomyopathy are exertional angina, dyspnea, fatigue, and impaired consciousness (transient spells of lightheadedness, near-syncope, and syncope). However, a direct, one-to-one correlation between a particular symptom and a single pathophysiologic mechanism does not always exist. For example, in a population of patients with hypertrophic cardiomyopathy, a general relation exists between the severity of symptoms and the magnitude of left ventricular hypertrophy19; however, this correlation is not absolute, and some patients with mild and localized hypertrophy may have severe symptoms,36 whereas other patients with.

Original languageEnglish (US)
Pages (from-to)844-852
Number of pages9
JournalNew England Journal of Medicine
Issue number14
StatePublished - Apr 2 1987

ASJC Scopus subject areas

  • Medicine(all)


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