Hypocapnia, ischemic lesions, and outcomes after intracerebral hemorrhage

Shannon Hextrum, Jatinder S. Minhas, Eric M. Liotta, Farzaneh A. Sorond, Andrew M. Naidech, Matthew B. Maas*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Background: An association between spontaneous hyperventilation, delayed cerebral ischemia, and poor clinical outcomes has been reported in subarachnoid hemorrhage. We evaluated the relationship between early pCO2 changes, ischemic lesions and outcomes in patients with intracerebral hemorrhage (ICH). Methods: Consecutive patients with spontaneous ICH were enrolled in an observational cohort study conducted between 2006 and 2019. Patient characteristics and discharge outcome were prospectively recorded. Arterial blood gas (ABG) measurements and mechanical ventilation settings in the first 72 h of admission were retrospectively collected. MRI images were adjudicated for diffusion-restricted lesions consistent with ischemia and distant from the hematoma. We examined the associations between pCO2 changes, ischemic lesions, and discharge outcomes by univariate and adjusted analyses. Results: ABG data were available for 220 patients. Hyperventilation occurred in 52 (28%) cases and was not associated with clinical severity. Lower initial pCO2 was associated with greater risk of in-hospital death (OR 0.94 per mmHg, 95%CI [0.89, 0.996], p = 0.042) after adjustment for ICH Score, pneumonia and mechanical ventilation requirements. MRI data were available for 33 patients. Lower pCO2 was associated with a higher risk of ischemic lesions, except in patients with low initial systolic blood pressure (p < 0.05 for main and blood pressure interaction effects), after adjustment for other predictors. Conclusions: In ICH patients with spontaneous ventilation, lower pCO2 was independently associated with greater risk of in-hospital death. In patients with elevated initial blood pressure, who undergo blood pressure reduction per guideline recommendations, lower pCO2 was associated with increased risk to develop ischemic lesions.

Original languageEnglish (US)
Article number117139
JournalJournal of the Neurological Sciences
Volume418
DOIs
StatePublished - Nov 15 2020

Keywords

  • Hyperventilation
  • Hypocapnia
  • Intracerebral hemorrhage
  • Outcomes

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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