Hypogammaglobulinemia associated with cytomegalovirus pneumonia

Paul A. Greenberger*, Cheryl L. Walker, Therese E. Fitzsimons, Mary Roberts

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Transient but profound hypogammaglobulinemia occurred during cytomegalovirus (CMV) pneumonia in a patient who developed striking declines in number of T lymphocytes. A 66-year-old, female, human immunodeficiency virus-negative patient requiring long-term hemodialysis had normal serum immunoglobulin concentrations before the onset of CMV pneumonia (IgG, 1070-1470 mg/dl; IgA, 94-102 mg/dl; IgM, 30-48 mg/dl). During the pneumonia episode, serum immunoglobulin concentrations were profoundly reduced (IgG, 440 mg/dl; IgA, 40 mg/dl; IgM, 25 mg/dl). Total lymphocytes declined from 3048/mm3 to 212/mm3 with reductions in CD4+CD45- lymphocytes (inducers of B cells) to 9% (nl, 24%-32%) and CD4+CD45+ lymphocytes (inducers of suppressor T cells) to 4% (nl, 14%-22%). CD8 lymphocytes were reduced to 5% (nl, 19%-31%). As the pneumonia resolved, serum immunoglobulin concentrations returned to normal. This is one of the few reported instances of CMV infection apparently causing hypogammaglobulinemia.

Original languageEnglish (US)
Pages (from-to)631-633
Number of pages3
JournalJournal of Infectious Diseases
Issue number3
StatePublished - Mar 1991

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases


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