Hypoglycemia due to antiinsulin receptor antibodies in systemic lupus erythematosus

J. Varga*, M. Lopatin, G. Boden

*Corresponding author for this work

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

An elderly woman with unexplained episodic fasting hypoglycemia was hospitalized for ascites. Evaluation revealed polyserositis, arthritis and immunologic abnormalities that suggested the diagnosis of systemic lupus erythematosus (SLE). Antibodies to insulin receptor with insulin binding inhibitory activity were detected in her serum. Treatment with prednisone was accompanied by resolution of hypoglycemic episodes and disappearance of the antireceptor antibodies. Autoantibody mediated alterations in serum glucose may be included in the growing list of autoimmune phenomena in SLE. Antiinsulin receptor antibodies should be sought in patients with SLE and idiopathic hypoglycemia.

Original languageEnglish (US)
Pages (from-to)1226-1229
Number of pages4
JournalJournal of Rheumatology
Volume17
Issue number9
StatePublished - 1990

Keywords

  • Antiinsulin receptor antibodies
  • Hypoglycemia
  • Systemic lupus erythematosus

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology

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