Hypokalemia in pregnancy: Clue to gitelman syndrome

Andrée De Bustros*, Grazia Aleppo, Demetrios Zikos

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


A normotensive 38-year-old woman had severe hypokalemia and metabolic alkalosis in her 16th week of pregnancy. She also had hypomagnesemia and hypocalciuria and evidence of activation of the renin/aldosterone system. DNA analysis revealed a mutation in the sodium chloride co-transporter gene, NCCT, located in the distal renal tubule. Gitelman syndrome was diagnosed, and she required massive potassium and magnesium supplements during pregnancy. She delivered, uneventfully, a healthy baby girl. We review the molecular pathophysiology of Gitelman syndrome and related tubular disorders and discuss management in pregnancy.

Original languageEnglish (US)
Pages (from-to)447-450
Number of pages4
Issue number6
StatePublished - Jan 1 2001

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism


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