Hyponatremia-associated cognitive impairment in traumatic brain injury

James W. Atchison*, Judith Wachendorf, David Haddock, W. Jerry Mysiw, Michael Gribble, John D. Corrigan

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


The case of a traumatic brain injury (TBI) patient with dramatic cognitive deterioration in the absence of medical aetiology other than simultaneous decline in serum sodium led to an investigation of the association between declines in sodium levels and cognitive status. In a population of 50 persons undergoing TBI rehabilitation, 12 (24% had relative (3 mEq/L) decreases in serum sodium while five (10% experienced absolute hyponatremia (136 mEq/L). Correlation with cognitive status was significant when the absolute hyponatremia group was compared with those whose sodium levels remained above 136 mEq/L. A case-matched study of the relative hyponatremia group yielded no significant association between sodium-level decreases and cognitive status. These data support previous conclusions indicating wide variation in individual responses to changes in serum sodium. The threshold for significant effects of hyponatremia may be higher in patients with TBI than in populations studied previously.

Original languageEnglish (US)
Pages (from-to)347-352
Number of pages6
JournalBrain Injury
Issue number4
StatePublished - Jan 1 1993

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Developmental and Educational Psychology
  • Clinical Neurology


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