TY - JOUR
T1 - Hypothalamic-pituitary-adrenal axis suppression after short-term, high-dose glucocorticoid therapy in children with asthma
AU - Zora, John A.
AU - Zimmerman, Donald
AU - Carey, Terence L.
AU - O'Connell, Edward J.
AU - Yunginger, John W.
N1 - Funding Information:
From the Department of Pediatrics, Mayo Graduate School of Med-icine, and the Allergic Diseases Research Laboratory, Mayo Clinic and Foundation, Rochester, Minn. Supported in part by Grant RR-585 from the National Institutes of Health and by Mayo Foundation. Received for publication Sept. 19, 1984. Accepted for publication May 20, 198.5. Reprint requests: J. W. Yunginger, M.D., Allergic Diseases Re-search Laboratory, 406 Guggenheim Building, Mayo Clinic, Rochester, MN 55905. *Received a fellowship award from Ciba-Geigy for this study.
PY - 1986/1
Y1 - 1986/1
N2 - Short-term, high-dose oral glucocorticoid therapy is often required for control of acute asthma episodes in children. To evaluate possible hypothalamic-pituitary-adrenal (HPA) axis suppression after such therapy, we studied 11 children with just asymptomatic asthma before and at 3 and 10 days after completion of a five-day course of prednisone (up to 2 mg/kg/day in divided doses, maximum dose = 60 mg/day). HPA axis responsiveness was tested by measuring plasma corticosteroid levels before and after insulin-induced hypoglycemia. When these levels were compared to pretreatment levels, there was a statistically significant blunting of the peak corticosteroid responses to hypoglycemia 3 days after completion of the course of prednisone (p < 0.001). However, corticosteroid responses were normal in all children 10 days after completion of the course of prednisone. We concluded that a single course of short-term, high-dose glucocorticoid therapy in children with asymptomatic asthma produces only transient (<10 days) HPA axis suppression.
AB - Short-term, high-dose oral glucocorticoid therapy is often required for control of acute asthma episodes in children. To evaluate possible hypothalamic-pituitary-adrenal (HPA) axis suppression after such therapy, we studied 11 children with just asymptomatic asthma before and at 3 and 10 days after completion of a five-day course of prednisone (up to 2 mg/kg/day in divided doses, maximum dose = 60 mg/day). HPA axis responsiveness was tested by measuring plasma corticosteroid levels before and after insulin-induced hypoglycemia. When these levels were compared to pretreatment levels, there was a statistically significant blunting of the peak corticosteroid responses to hypoglycemia 3 days after completion of the course of prednisone (p < 0.001). However, corticosteroid responses were normal in all children 10 days after completion of the course of prednisone. We concluded that a single course of short-term, high-dose glucocorticoid therapy in children with asymptomatic asthma produces only transient (<10 days) HPA axis suppression.
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U2 - 10.1016/0091-6749(86)90315-5
DO - 10.1016/0091-6749(86)90315-5
M3 - Article
C2 - 3944378
AN - SCOPUS:0022634355
SN - 0091-6749
VL - 77
SP - 9
EP - 13
JO - Journal of Allergy and Clinical Immunology
JF - Journal of Allergy and Clinical Immunology
IS - 1 PART 1
ER -