Hypothermia and hemostasis in severe trauma: A new crossroads workshop report

Hasan B. Alam*, Anthony E. Pusateri, Andrei Kindzelski, Debra Egan, Keith Hoots, Matthew T. Andrews, Peter Rhee, Samuel Tisherman, Kenneth Mann, Jaroslav Vostal, Patrick M. Kochanek, Thomas Scalea, Virgil Deal, Forest Sheppard, George Sopko

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

23 Scopus citations


OBJECTIVE: The hypothermia and hemostasis in severe trauma (HYPOSTAT): a new crossroads workshop was convened to evaluate the interplay among hypothermia, hemostasis, and severe trauma/hemorrhage. Trauma is the major cause of death in young individuals in the United States, with uncontrolled hemorrhage representing the major cause of preventable deaths. DATA SOURCES: This workshop organized by the National Heart, Lung, and Blood Institute and the US Army Medical Research and Material Command as a forum for exchange of ideas among experts from diverse fields. The specific workshop goals were to (1) identify state-of-the-art and needs in knowledge of biology of hypothermia and hemostasis in the setting of significant traumatic injury; (2) provide an interdisciplinary forum to enhance knowledge regarding early detection of traumatic shock and monitoring of the level and effect of controlled hypothermia in severe trauma settings; and (3) identify future research directions of the role of therapeutic-oriented hypothermia and hemostasis in trauma with severe blood loss. STUDY SELECTION: Not applicable. DATA EXTRACTION: Expert opinion and literature review. CONCLUSION: This document provides a summary of the expert opinion and highlights the recommendations that came out of the discussions at this workshop to guide scientific efforts in basic, translational, and clinical research in this area.

Original languageEnglish (US)
Pages (from-to)809-817
Number of pages9
JournalJournal of Trauma and Acute Care Surgery
Issue number4
StatePublished - Oct 2012
Externally publishedYes


  • Hypothermia
  • coagulopathy
  • injury
  • protection
  • trauma

ASJC Scopus subject areas

  • Surgery
  • Critical Care and Intensive Care Medicine


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