Hypothesis: AIDS encephalopathy is due to primary and persistent infection of the brain with a human retrovirus of the lentivirus subfamily

Leon G. Epstein*, Leroy R. Sharer, D. Carleton Gajdusek

*Corresponding author for this work

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Recent evidence has demonstrated that human T-lymphotropic retroviruses are present in the brain of patients with acquired immunodeficiency syndrome (AIDS). Studies by neuropathological, ultrastructural and nucleic acid hybridization techniques indicate that these human retroviruses are neurotropic as well as lymphotropic. Striking similarities to the animal retroviruses of the lentivirus subfamily provide a rationale to implicate these human retroviruses (lentiviruses) in the pathogenesis of AIDS encephalopathy.

Original languageEnglish (US)
Pages (from-to)87-96
Number of pages10
JournalMedical Hypotheses
Volume21
Issue number1
DOIs
StatePublished - Sep 1986

ASJC Scopus subject areas

  • Medicine(all)

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