Hypotony in patients with uveitis: The Multicenter Uveitis Steroid Treatment (MUST) trial

H. Nida Sen*, Lea T. Drye, Debra A. Goldstein, Theresa A. Larson, Pauline T. Merrill, Peter R. Pavan, John D. Sheppard, Alyce Burke, Sunil K. Srivastava, Douglas A. Jabs

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

33 Scopus citations


Purpose: To assess the prevalence of hypotony in patients with severe forms of uveitis. Methods: The Multicenter Uveitis Steroid Treatment (MUST) Trial, a randomized study, enrolled 255 patients. Patients with hypotony at the baseline visit were identified. Results: Twenty (8.3%) of 240 patients with sufficient data had hypotony. Hypotony was more common in patients with uveitis ≥5 years duration (odds ratio [OR]=5.0; p <.01), and in eyes with a history of ocular surgery (vitrectomy vs. none, OR=3.1; p=.03). Hypotony was less in patients with older age of uveitis onset (>51 years vs. <51 years, OR=0.1; p=.02), in Caucasian patients (OR=0.1; p <.01) compared to African American patients. Hypotonous eyes were more likely to have visual impairment (OR=22.9; p <.01). Conclusions: Hypotony is an important complication of uveitis and more commonly affects African-American patients, those with uveitis onset at a younger age, and those with longer disease duration. It is associated with visual impairment.

Original languageEnglish (US)
Pages (from-to)104-112
Number of pages9
JournalOcular Immunology and Inflammation
Issue number2
StatePublished - Apr 2012


  • Hypotony
  • Multicenter uveitis steroid treatment trial
  • Uveitis
  • Visual impairment
  • Visual loss

ASJC Scopus subject areas

  • Immunology and Allergy
  • Ophthalmology


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